Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6798370 | 0.93 | GPR132 (0.42) | ACEITGB3ITGA2BTSHRACE2 | |
| SCHEMBL4452919 | 0.92 | ACE (0.47) | ACEITGB3ITGA2BTSHRACE2 | |
| SCHEMBL4451224 | 0.89 | ITGB3 (0.41) | ACEITGB3ITGA2BTSHRCTSL | |
| SCHEMBL4454188 | 0.88 | ITGB3 (0.40) | ACEITGB3ITGA2B | |
| SCHEMBL4454262 | 0.87 | ITGB3 (0.42) | ACEITGB3ITGA2BTSHRACE2 | |
| SCHEMBL6804307 | 0.87 | KMT2A (0.49) | ACETSHRACE2CTSLKMT2A | |
| SCHEMBL4458967 | 0.86 | CTSK (0.47) | ACEITGB3ITGA2BTSHRACE2 | |
| SCHEMBL4452835 | 0.86 | ITGB3 (0.41) | ACEITGB3ITGA2BTSHRACE2 | |
| SCHEMBL4458898 | 0.86 | ITGB3 (0.41) | ACEITGB3ITGA2BTSHRCTSL | |
| SCHEMBL6798893 | 0.85 | CHRNA1 (0.42) | ACE2CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040138250-A1 | Inhibitors of cruzipain and other cysteine proteases | GRUNENTHAL GMBH (DE) | 2004-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138250-A1 | Inhibitors of cruzipain and other cysteine proteases | CPN1, CTRL, CPA1 | ACE 371/4885ITGB3 3028/4885ITGA2B 1974/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.