Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 6/20 | 0.47 |
| ▸ | HTR2C | P28335 | 6/20 | 0.47 |
| ▸ | HTR2B | P41595 | 6/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 4/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6800174 | 0.92 | PBRM1 (0.49) | PBRM1HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL6798794 | 0.88 | HTR2A (0.47) | HTR2AHTR2CHTR2BSIGMAR1MAOB | |
| SCHEMBL6794055 | 0.87 | ESR1 (0.44) | PBRM1MAOBMAPK14ESR1ESR2 | |
| SCHEMBL6806169 | 0.83 | MAOA (0.46) | PBRM1HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL6800723 | 0.83 | ESR2 (0.46) | PBRM1MAOBESR1ESR2MAOA | |
| SCHEMBL7943845 | 0.82 | SIGMAR1 (0.65) | HTR2AHTR2CHTR2BSIGMAR1MAOB | |
| SCHEMBL1463869 | 0.81 | TDP1 (0.53) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| SCHEMBL6798898 | 0.80 | SMN1; SMN2 (0.43) | HTR2AHTR2CHTR2BSIGMAR1MAOB | |
| SCHEMBL6794708 | 0.79 | PBRM1 (0.46) | PBRM1MAOBESR1ESR2MAOA | |
| SCHEMBL6801984 | 0.78 | SIGMAR1 (0.54) | HTR2AHTR2CHTR2BSIGMAR1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040082642-A1 | Novel estrogen receptor ligands and method III | MERCK & CO., INC. | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082642-A1 | Novel estrogen receptor ligands and method III | ESRRA, ESRRB, FSHR | PBRM1 4775/4885HTR2A 850/4885HTR2C 795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.