Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6790235 | 0.86 | NR1H2 (0.35) | ALDH1A1SMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL6792153 | 0.86 | ALDH1A1 (0.32) | ALDH1A1HPGDMEN1KMT2ANR1H2 | |
| SCHEMBL6797707 | 0.80 | ALDH1A1 (0.48) | ALDH1A1NLRP3SMN1; SMN2TP53HPGD | |
| SCHEMBL6792774 | 0.71 | AURKA (0.43) | ALDH1A1NLRP3SMN1; SMN2TP53HPGD | |
| SCHEMBL6793837 | 0.63 | MAPT (0.39) | ALDH1A1SMN1; SMN2MEN1KMT2APKM | |
| SCHEMBL6795755 | 0.62 | MAPT (0.43) | ALDH1A1SMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL11058731 | 0.60 | ALDH1A1 (0.48) | ALDH1A1NLRP3SMN1; SMN2TP53HPGD | |
| SCHEMBL10795112 | 0.59 | MEN1 (0.56) | ALDH1A1NLRP3SMN1; SMN2MEN1KMT2A | |
| SCHEMBL27537313 | 0.57 | FKBP1A (0.60) | ALDH1A1HPGDFKBP1AMEN1KMT2A | |
| SCHEMBL5535608 | 0.56 | NR1H2 (0.42) | ALDH1A1HPGDMEN1KMT2ANR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | ALDH1A1 4449/4885NLRP3 2910/4885SMN1; SMN2 4333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.