Sugi Predict

Sugi Predict / Compounds / SCHEMBL6799493

SCHEMBL6799493

SCHEMBL6799493

O=c1c2cc(F)c(Cl)nc2n(-c2ccc(C(F)(F)F)cc2)c(=O)n1OCc1ccccc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PPARD Q03181 2/20 0.35
▸ PPARA Q07869 2/20 0.35
▸ CXCR3 P49682 3/20 0.34
▸ MAT2A P31153 1/20 0.34
▸ CFTR P13569 1/20 0.34
▸ ALDH1A1 P00352 2/20 0.34
▸ TSHR P16473 1/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ CYP1A2 P05177 1/20 0.34
▸ CYP3A4 P08684 1/20 0.34
▸ CYP2C9 P11712 1/20 0.34
▸ CYP2C19 P33261 1/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ TRPV4 Q9HBA0 1/20 0.33
▸ POLB P06746 1/20 0.33
▸ PTGER1 P34995 1/20 0.33
▸ KCNQ3 O43525 1/20 0.33
▸ KCNQ2 O43526 1/20 0.33
▸ KCNQ1 P51787 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6800611 0.91 CTSK (0.40) MAT2ATSHRCYP1A2MAOAMAOB
SCHEMBL6798905 0.90 ALDH1A1 (0.42) ALDH1A1TSHRL3MBTL1CYP1A2CYP3A4
SCHEMBL6801352 0.89 ALDH1A1 (0.39) ALDH1A1TSHRL3MBTL1CYP1A2CYP3A4
SCHEMBL6797355 0.87 ALDH1A1 (0.43) ALDH1A1TSHRCYP1A2CYP3A4CYP2C9
SCHEMBL6803474 0.85 TRPV4 (0.36) PPARDPPARACXCR3MAT2AALDH1A1
SCHEMBL6795249 0.84 PDE4A (0.41) ALDH1A1TSHRL3MBTL1CYP1A2CYP3A4
SCHEMBL6797211 0.81 GLA (0.42) ALDH1A1TSHRL3MBTL1CYP1A2CYP3A4
SCHEMBL6801045 0.80 MAPT (0.41) ALDH1A1TSHRL3MBTL1CYP1A2CYP3A4
SCHEMBL6796950 0.78 ALDH1A1 (0.40) ALDH1A1TSHRL3MBTL1CYP1A2CYP3A4
SCHEMBL6798896 0.76 TSHR (0.38) ALDH1A1TSHRCYP1A2KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6825199-B2 7-Substituted quinazolin-2,4-diones useful as antibacterial agents WARNER-LAMBERT COMPANY 2004-11-30 — — US claimed
EP-1028950-B1 7-SUBSTITUTED QUINAZOLIN-2,4-DIONES USEFUL AS ANTIBACTERIAL AGENTS WARNER LAMBERT CO (US) 2003-05-02 — — EP claimed
US-20020115674-A1 Novel 7-substituted quinazolin-2,4-diones useful as antibacterial agents DOMAGALA JOHN MICHAEL (US) 2002-08-22 — — US claimed
US-6825199-B2 7-Substituted quinazolin-2,4-diones useful as antibacterial agents WARNER-LAMBERT COMPANY 2004-11-30 — — US disclosed
EP-1028950-B1 7-SUBSTITUTED QUINAZOLIN-2,4-DIONES USEFUL AS ANTIBACTERIAL AGENTS WARNER LAMBERT CO (US) 2003-05-02 — — EP disclosed
US-20020115674-A1 Novel 7-substituted quinazolin-2,4-diones useful as antibacterial agents DOMAGALA JOHN MICHAEL (US) 2002-08-22 — — US disclosed
US-6331538-B1 TREATMENT OF BACTERIAL INFECTION WARNER-LAMBERT COMPANY 2001-12-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020115674-A1 Novel 7-substituted quinazolin-2,4-diones useful as antibacterial agents NQO2, TOP1, TOP2A PPARD 2830/4885PPARA 3461/4885CXCR3 1753/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.