Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.32 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.32 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.32 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6794711 | 0.89 | NPC1 (0.39) | NPC1RAB9ADPP4DPP7DPP8 | |
| SCHEMBL6799702 | 0.88 | PTGDR2 (0.32) | NPC1RAB9AKLKB1KCNK3PDPK1 | |
| Trifluoroacetic Acid SCHEMBL6792278 | 0.88 | RORC (0.36) | NPC1RAB9ADPP4DPP7PDPK1 | |
| Trifluoroacetic Acid SCHEMBL6792875 | 0.88 | GABRA1 (0.34) | PDPK1CDK2S1PR1S1PR3OPRD1 | |
| Trifluoroacetic Acid SCHEMBL1655968 | 0.87 | MPL (0.39) | KCNK3PDPK1CDK2S1PR1 | |
| Trifluoroacetic Acid SCHEMBL6794900 | 0.87 | RORC (0.34) | NPC1RAB9APDPK1CDK2PARP1 | |
| Trifluoroacetic Acid SCHEMBL1658162 | 0.85 | KCNK3 (0.37) | KCNK3 | |
| Trifluoroacetic Acid SCHEMBL6791782 | 0.85 | PDPK1 (0.33) | PDPK1CDK2OPRD1 | |
| Trifluoroacetic Acid SCHEMBL1656588 | 0.85 | GABRA1 (0.37) | PDPK1CDK2 | |
| Trifluoroacetic Acid SCHEMBL6794064 | 0.84 | NR1H4 (0.33) | KCNK3PDPK1CDK2OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | NPC1 4242/4885RAB9A 2148/4885HSP90AA1 936/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.