Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6800001 | 1.00 | LMNA (0.38) | LMNACYP2C9CHRM2CHRM1CHRM3 | |
| SCHEMBL4594933 | 0.76 | SLC6A1 (0.35) | LMNACHRNA7KMT2ACYP2D6 | |
| SCHEMBL8192973 | 0.70 | CHRM3 (0.35) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL6801641 | 0.70 | LMNA (0.45) | LMNACYP2C9CHRM2CHRM1CHRM3 | |
| SCHEMBL6801650 | 0.70 | LMNA (0.45) | LMNACYP2C9CHRM2CHRM1CHRM3 | |
| SCHEMBL27902620 | 0.65 | SLC6A2 (0.37) | MEN1KMT2ACYP2D6 | |
| SCHEMBL3235890 | 0.65 | SMN1; SMN2 (0.36) | — | |
| Trifluoroacetic Acid SCHEMBL25267493 | 0.65 | IRAK4 (0.37) | LMNACYP2C9CHRM2CHRM1CHRM3 | |
| SCHEMBL17699940 | 0.65 | SLC6A1 (0.47) | LMNAKMT2ACYP2D6 | |
| SCHEMBL272039 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6734306-B2 | USEFUL IN THE TREATMENT OF INFLAMMATION, ASTHMA, ALLERGIC RHINITIS, PAIN OR THE LIKE | PFIZER, INC. | 2004-05-11 | — | — | US | disclosed |
| US-20020128271-A1 | N-benzenesulfonyl l-proline compounds as bradykinin antagonists | PFIZER INC. | 2002-09-12 | — | — | US | disclosed |
| EP-1213289-A1 | N-benzenesulfonyl L-proline compounds as bradykinin antagonists | PFIZER INC. (US) | 2002-06-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020128271-A1 | N-benzenesulfonyl l-proline compounds as bradykinin antagonists | BDKRB1, HRH2, BDKRB2 | LMNA 1563/4885CYP2C9 1582/4885CHRM2 1985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.