Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 13/20 | 0.68 |
| ▸ | HTR2A | P28223 | 13/20 | 0.68 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 6/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6615634 | 1.00 | HTR2C (0.68) | HTR2CHTR2ASLC6A4KMT2AHTR2B | |
| SCHEMBL6618285 | 0.89 | HTR2C (0.66) | HTR2CHTR2ASLC6A4HTR2BKCNH2 | |
| SCHEMBL6618284 | 0.89 | HTR2C (0.66) | HTR2CHTR2ASLC6A4HTR2BKCNH2 | |
| SCHEMBL6616323 | 0.89 | SLC6A4 (0.57) | HTR2CHTR2ASLC6A4HTR2BKCNH2 | |
| SCHEMBL6793476 | 0.89 | SLC6A4 (0.57) | HTR2CHTR2ASLC6A4HTR2BKCNH2 | |
| SCHEMBL6798044 | 0.86 | SLC6A4 (0.55) | HTR2CHTR2ASLC6A4KMT2A | |
| SCHEMBL6627265 | 0.86 | SLC6A4 (0.55) | HTR2CHTR2ASLC6A4KMT2A | |
| SCHEMBL6804950 | 0.83 | SLC6A4 (0.60) | HTR2CHTR2ASLC6A4HTR2B | |
| SCHEMBL6618289 | 0.83 | SLC6A4 (0.60) | HTR2CHTR2ASLC6A4HTR2B | |
| SCHEMBL6670070 | 0.82 | HTR2A (0.69) | HTR2CHTR2ASLC6A4HTR2BKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6822100-B2 | REACTING N-SULFONYL-3-VINYLINDOLE WITH RUTHENIUM COMPLEX IN PRESENCE OF ETHYL DIAZOACETATE AND TOLUENE; PSYCHOLOGICAL, SEXUAL, AND EATING DISORDERS | BRISTOL-MYERS SQUIBB COMPANY | 2004-11-23 | — | — | US | disclosed |
| US-6777437-B2 | ANTIDEPRESSANTS, ANXIOLYTIC AGENTS. SEXUAL DISORDERS | BRISTOL-MYERS SQUIBB COMPANY | 2004-08-17 | — | — | US | disclosed |
| US-20040143003-A1 | Cyclopropylindole derivatives as selective serotonin reuptake inhibitors | MATTSON RONALD J (US) | 2004-07-22 | — | — | US | disclosed |
| US-20030073849-A1 | Cyclopropylindole derivatives as selective serotonin reuptake inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2003-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040143003-A1 | Cyclopropylindole derivatives as selective serotonin reuptake inhibitors | HTR1A, HTR1D, TPH1 | HTR2C 9/4885HTR2A 22/4885SLC6A4 16/4885 |
| US-20030073849-A1 | Cyclopropylindole derivatives as selective serotonin reuptake inhibitors | HTR5A, HTR1A, HTR2C | HTR2C 3/4885HTR2A 18/4885SLC6A4 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.