Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | MST1R | Q04912 | 1/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | CAMK4 | Q16566 | 1/20 | 0.41 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.35 |
| ▸ | FEN1 | P39748 | 3/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680085 | 0.84 | S1PR4 (0.44) | AXLPLK4NTRK1RETMET | |
| SCHEMBL680022 | 0.83 | CYP11B1 (0.43) | AXLPLK4NTRK1RETMET | |
| SCHEMBL23081429 | 0.82 | AXL (0.41) | AXLPLK4NTRK1RETMET | |
| SCHEMBL680039 | 0.82 | PLK4 (0.55) | AXLPLK4NTRK1RETMET | |
| SCHEMBL680260 | 0.79 | TLR8 (0.46) | AAK1ALOX5APFEN1TRPA1 | |
| SCHEMBL680999 | 0.78 | PLK4 (0.42) | AXLPLK4NTRK1RETMET | |
| SCHEMBL30896357 | 0.77 | CDC7 (0.41) | GRM2TRPA1ARIRAK4USP7 | |
| SCHEMBL31613173 | 0.74 | CDC7 (0.41) | GRM2TRPA1ARIRAK4USP7 | |
| SCHEMBL680838 | 0.74 | SCN9A (0.45) | AXLPLK4NTRK1RETMET | |
| SCHEMBL680681 | 0.74 | CACNA1H (0.42) | AXLPLK4NTRK1RETMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310382-B1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | LILLY CO ELI (US) | 2012-02-22 | — | — | EP | disclosed |