Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C known ✓ | P28335 | 5/20 | 0.40 |
| ▸ | HTR2A known ✓ | P28223 | 4/20 | 0.40 |
| ▸ | EIF2AK3 | Q9NZJ5 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMO | Q99835 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6802672 | 0.97 | EIF2AK3 (0.50) | EIF2AK3MAPTSMN1; SMN2NPC1TP53 | |
| SCHEMBL6667059 | 0.94 | EIF2AK3 (0.48) | EIF2AK3MAPTSMN1; SMN2NPC1TP53 | |
| SCHEMBL6803779 | 0.92 | EIF2AK3 (0.48) | EIF2AK3MAPTSMN1; SMN2NPC1TP53 | |
| SCHEMBL6806302 | 0.92 | EIF2AK3 (0.48) | EIF2AK3MAPTSMN1; SMN2NPC1TP53 | |
| Hydrochloric Acid SCHEMBL6808953 | 0.92 | EIF2AK3 (0.47) | EIF2AK3MAPTSMN1; SMN2NPC1TP53 | |
| SCHEMBL6798695 | 0.91 | HTR2C (0.49) | EIF2AK3MAPTSMN1; SMN2NPC1TP53 | |
| SCHEMBL6668503 | 0.91 | EIF2AK3 (0.51) | EIF2AK3MAPTSMN1; SMN2NPC1TP53 | |
| SCHEMBL6805146 | 0.91 | EIF2AK3 (0.47) | EIF2AK3MAPTSMN1; SMN2NPC1TP53 | |
| SCHEMBL6799317 | 0.91 | EIF2AK3 (0.47) | EIF2AK3MAPTSMN1; SMN2NPC1TP53 | |
| SCHEMBL6667964 | 0.90 | EIF2AK3 (0.50) | EIF2AK3MAPTSMN1; SMN2NPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040157866-A1 | Amide compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040157866-A1 | Amide compounds | APOB, NR1H2, NR1H3 | HTR2C 2433/4885HTR2A 2176/4885EIF2AK3 2638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.