Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.45 |
| ▸ | MMP13 | P45452 | 3/20 | 0.44 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17971206 | 0.91 | KDM4E (0.62) | KDM4ELMNASCN9ASMN1; SMN2HPGD | |
| SCHEMBL679782 | 0.86 | SCN9A (0.50) | KDM4ELMNASCN9ASMN1; SMN2HPGD | |
| SCHEMBL16319859 | 0.84 | MMP1 (0.56) | LMNASCN9ASMN1; SMN2HPGDTSHR | |
| SCHEMBL21628436 | 0.84 | HDAC6 (0.59) | SMN1; SMN2HPGDTSHRHTTNPC1 | |
| SCHEMBL680561 | 0.83 | MMP13 (0.65) | SCN9ASMN1; SMN2HPGDTSHRHTT | |
| SCHEMBL680791 | 0.83 | CA1 (0.61) | SMN1; SMN2HPGDTSHRHTTNPC1 | |
| SCHEMBL703171 | 0.81 | BCL2L1 (0.59) | SCN9ASMN1; SMN2HPGDTSHRHTT | |
| SCHEMBL20482354 | 0.81 | SMN1; SMN2 (0.76) | SMN1; SMN2HPGDTSHRHTTNPC1 | |
| SCHEMBL680556 | 0.79 | SCN9A (0.68) | SCN9ASMN1; SMN2HPGDTSHRHTT | |
| SCHEMBL680849 | 0.79 | PTPN1 (0.52) | LMNASCN9ASMN1; SMN2HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |
| US-20120010207-A1 | Chemical Compounds | PFIZER LIMITED (GB) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010207-A1 | Chemical Compounds | SCN1A, SCN1B, SCN7A | KDM4E 3006/4885LMNA 2892/4885SCN9A 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.