Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MYC | P01106 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680519 | 0.86 | L3MBTL1 (0.63) | ALDH1A1NOTUMKDM4EL3MBTL1GAA | |
| SCHEMBL6751094 | 0.86 | NOTUM (0.57) | ALDH1A1NOTUMKDM4EL3MBTL1GAA | |
| SCHEMBL9251071 | 0.84 | NOTUM (0.56) | ALDH1A1NOTUMKDM4EL3MBTL1GAA | |
| SCHEMBL28230986 | 0.84 | ALDH1A1 (0.51) | ALDH1A1NOTUMKDM4EL3MBTL1GAA | |
| SCHEMBL679393 | 0.82 | MEN1 (0.60) | ALDH1A1KDM4EL3MBTL1GAAMEN1 | |
| SCHEMBL11462311 | 0.80 | NOTUM (0.59) | ALDH1A1NOTUMKDM4EL3MBTL1GFER | |
| SCHEMBL2285212 | 0.78 | L3MBTL1 (0.74) | ALDH1A1NOTUMKDM4EL3MBTL1GAA | |
| SCHEMBL9740604 | 0.77 | KMT2A (0.44) | ALDH1A1NOTUMKDM4EL3MBTL1GAA | |
| SCHEMBL11626756 | 0.77 | NOTUM (0.63) | ALDH1A1NOTUMKDM4EL3MBTL1GAA | |
| SCHEMBL1976260 | 0.77 | GAA (0.52) | ALDH1A1NOTUMKDM4EL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310382-B1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | LILLY CO ELI (US) | 2012-02-22 | — | — | EP | disclosed |
| CN-102105462-A | Amidophenoxyindazoles useful as inhibitors of C-MET | LILLY CO ELI | 2011-06-22 | — | — | CN | disclosed |