Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | TOP2A | P11388 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL679136 | 0.87 | KDM4E (0.64) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL6214409 | 0.85 | KDM4E (0.61) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL6214412 | 0.83 | KDM4E (0.48) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL679171 | 0.82 | ALDH1A1 (0.42) | KDM4EALDH1A1HPGDHSD17B10TOP2A | |
| SCHEMBL8802473 | 0.81 | KDM4E (0.66) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL13483563 | 0.80 | ALDH1A1 (0.58) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL8741154 | 0.79 | KDM4E (0.51) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL680312 | 0.79 | KDM4E (0.54) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL8572108 | 0.77 | KDM4E (0.71) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL10657002 | 0.76 | KDM4E (0.52) | KDM4EALDH1A1LMNAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120108557-A1 | FLUOROQUINOLONE DERIVATIVES FOR OPHTHALMIC APPLICATIONS | ALCON RESEARCH, LTD. (US) | 2012-05-03 | — | — | US | disclosed |
| US-20110160172-A1 | FLUOROQUINOLONE DERIVATIVES FOR OPHTHALMIC APPLICATIONS | ALCON RESEARCH, LTD. (US) | 2011-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160172-A1 | FLUOROQUINOLONE DERIVATIVES FOR OPHTHALMIC APPLICATIONS | QARS1, UACA, CYP51A1 | KDM4E 392/4885ALDH1A1 4160/4885LMNA 3373/4885 |
| US-20120108557-A1 | FLUOROQUINOLONE DERIVATIVES FOR OPHTHALMIC APPLICATIONS | QARS1, UACA, CYP51A1 | KDM4E 392/4885ALDH1A1 4160/4885LMNA 3373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.