Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12194496 | 1.00 | LMNA (0.46) | LMNASMN1; SMN2AOC3SLC6A4SLC6A2 | |
| SCHEMBL12194484 | 0.87 | AOC3 (0.41) | LMNASMN1; SMN2AOC3SLC6A4SLC6A2 | |
| SCHEMBL681322 | 0.87 | AOC3 (0.41) | LMNASMN1; SMN2AOC3SLC6A4SLC6A2 | |
| SCHEMBL12194497 | 0.86 | AOC3 (0.41) | LMNASMN1; SMN2AOC3SLC6A4SLC6A2 | |
| SCHEMBL681286 | 0.84 | UTS2R (0.46) | SLC6A4SLC6A2KCNH2L3MBTL1UTS2R | |
| SCHEMBL681223 | 0.83 | LMNA (0.46) | LMNASMN1; SMN2AOC3SLC6A4SLC6A2 | |
| SCHEMBL12193952 | 0.83 | LMNA (0.46) | LMNASMN1; SMN2AOC3SLC6A4SLC6A2 | |
| SCHEMBL12292982 | 0.81 | AOC3 (0.49) | LMNASMN1; SMN2AOC3SLC6A4SLC6A2 | |
| SCHEMBL12188470 | 0.79 | BRD4 (0.50) | LMNASMN1; SMN2AOC3SLC6A4SLC6A2 | |
| SCHEMBL12194482 | 0.79 | GABBR2 (0.45) | LMNASMN1; SMN2AOC3MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |