Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 2/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12194484 | 1.00 | AOC3 (0.41) | AOC3AKT1AKT2AKT3POLB | |
| SCHEMBL12194496 | 0.87 | LMNA (0.46) | AOC3POLBLMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL680133 | 0.87 | LMNA (0.46) | AOC3POLBLMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL679658 | 0.84 | POLB (0.42) | AOC3AKT1AKT2AKT3POLB | |
| SCHEMBL681624 | 0.84 | PYCR1 (0.40) | POLB | |
| SCHEMBL12367542 | 0.84 | POLB (0.42) | AOC3AKT1AKT2AKT3POLB | |
| SCHEMBL21506836 | 0.83 | AOC3 (0.41) | AOC3AKT1AKT2AKT3POLB | |
| SCHEMBL12194497 | 0.83 | AOC3 (0.41) | AOC3POLBLMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL12188541 | 0.83 | BRD4 (0.46) | AOC3AKT1AKT2AKT3POLB | |
| SCHEMBL8223669 | 0.83 | BRD4 (0.46) | AOC3AKT1AKT2AKT3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |