Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6801337 | 1.00 | HSD11B1 (0.38) | HSD11B1GRIN1GRIN2AGRIN2BGPR119 | |
| SCHEMBL6203970 | 0.84 | RAB9A (0.39) | HSD11B1GRIN1GRIN2AGRIN2BHTT | |
| SCHEMBL6203975 | 0.84 | RAB9A (0.39) | HSD11B1GRIN1GRIN2AGRIN2BHTT | |
| SCHEMBL30264915 | 0.73 | JAK2 (0.34) | XPO1RXRARXRBRXRGJAK2 | |
| SCHEMBL24608781 | 0.71 | HSD11B1 (0.42) | HSD11B1GRIN1GRIN2AGRIN2BGPR119 | |
| SCHEMBL1256110 | 0.71 | GRIN1 (0.50) | HSD11B1GRIN1GRIN2AGRIN2BHTT | |
| SCHEMBL1255067 | 0.71 | GRIN1 (0.50) | HSD11B1GRIN1GRIN2AGRIN2BHTT | |
| SCHEMBL1253508 | 0.71 | GRIN1 (0.50) | HSD11B1GRIN1GRIN2AGRIN2BHTT | |
| SCHEMBL1255604 | 0.71 | GRIN1 (0.50) | HSD11B1GRIN1GRIN2AGRIN2BHTT | |
| SCHEMBL28341507 | 0.71 | GPR119 (0.47) | GPR119CYP3A4CYP2C19OPRK1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040063643-A1 | Bombesin antagonists | PFIZER INC. | 2004-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063643-A1 | Bombesin antagonists | BRS3, NPSR1, GNRHR | HSD11B1 602/4885GRIN1 780/4885GRIN2A 1010/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.