Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.38 |
| ▸ | MC4R | P32245 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.36 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.36 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.35 |
| ▸ | BID | P55957 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17803808 | 1.00 | SIGMAR1 (0.38) | SIGMAR1MC4RDPP4DPP7AKT1 | |
| SCHEMBL681313 | 0.90 | MEN1 (0.37) | SIGMAR1MC4RNTSR1ALDH1A1BCL2A1 | |
| SCHEMBL681578 | 0.90 | MEN1 (0.37) | SIGMAR1MC4RNTSR1ALDH1A1BCL2A1 | |
| SCHEMBL680103 | 0.89 | DPP4 (0.42) | SIGMAR1DPP4DPP7AKT1AKT2 | |
| SCHEMBL680779 | 0.88 | MC4R (0.39) | SIGMAR1MC4RDPP4DPP7AKT1 | |
| SCHEMBL681277 | 0.88 | MC4R (0.39) | SIGMAR1MC4RDPP4DPP7AKT1 | |
| SCHEMBL17803801 | 0.86 | OPRK1 (0.41) | SIGMAR1CCR5 | |
| SCHEMBL684553 | 0.85 | HRH2 (0.41) | SIGMAR1DPP4DPP7AKT1AKT2 | |
| SCHEMBL683470 | 0.85 | HRH2 (0.41) | SIGMAR1DPP4DPP7AKT1AKT2 | |
| SCHEMBL12194511 | 0.84 | HSD11B1 (0.44) | SIGMAR1MC4RAKT1AKT2AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |