Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 2/20 | 0.53 |
| ▸ | GBA1 | P04062 | 1/20 | 0.50 |
| ▸ | CASP6 | P55212 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | SMO | Q99835 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29931498 | 0.87 | NCF1 (0.42) | NCF1GBA1HRH4HSD17B10 | |
| SCHEMBL21192964 | 0.84 | GBA1 (0.66) | NCF1GBA1SMOTP53MAPT | |
| SCHEMBL11823091 | 0.82 | MEN1 (0.55) | PTPN11TP53MAPTHSD17B10 | |
| SCHEMBL29931618 | 0.81 | PIK3CA (0.48) | GBA1PIK3CAPTPN11MAP4K4MAPT | |
| SCHEMBL27029463 | 0.81 | PIK3CA (0.48) | GBA1PIK3CAPTPN11MAP4K4MAPT | |
| SCHEMBL10143602 | 0.77 | HRH4 (0.54) | NCF1HRH4HSD17B10 | |
| SCHEMBL19690964 | 0.76 | CASP6 (0.51) | NCF1GBA1CASP6GFERCLK1 | |
| SCHEMBL10143604 | 0.76 | HRH4 (0.53) | NCF1HRH4HSD17B10 | |
| SCHEMBL29970452 | 0.76 | GBA1 (0.51) | NCF1GBA1CASP6GFERPIK3CA | |
| SCHEMBL6800518 | 0.75 | ACHE (0.55) | NCF1GBA1CASP6GFERSMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040063720-A1 | Tyrosine kinase inhibitors | MERCK & CO., INC. | 2004-04-01 | — | — | US | disclosed |
| US-20020137755-A1 | Tyrosine kinase inhibitors | BILODEAU MARK T (US) | 2002-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020137755-A1 | Tyrosine kinase inhibitors | ERBB2, TYRO3, TIE1 | NCF1 920/4885GBA1 2573/4885CASP6 961/4885 |
| US-20040063720-A1 | Tyrosine kinase inhibitors | ERBB2, TYRO3, TIE1 | NCF1 920/4885GBA1 2573/4885CASP6 961/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.