SCHEMBL680178

SCHEMBL680178

C1=C\Cc2ccccc2O\N=C/1

nearest known ligand 0.34

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.34
MAOB P27338 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8925 0.75 MAOA (0.39) MAOAMAOB
SCHEMBL31513481 0.75 MAOA (0.39) MAOAMAOB
Methylamine SCHEMBL6415772 0.74 MAOA (0.35) MAOAMAOB
SCHEMBL7679301 0.74 MAOA (0.38) MAOAMAOB
Hydrochloric Acid SCHEMBL8707066 0.74 MAOA (0.38) MAOAMAOB
Methane SCHEMBL28285761 0.74 MAOA (0.38) MAOAMAOB
Water SCHEMBL15284972 0.74 MAOA (0.38) MAOAMAOB
Hydrochloric Acid SCHEMBL8699855 0.74 MAOA (0.38) MAOAMAOB
SCHEMBL3927587 0.73
SCHEMBL5525165 0.69 MAOA (0.38) MAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 180 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101829328-B Medicine for treating amphetamine type stimulant dependency and mixed dependency of amphetamine type stimulant dependency and opium LU ZHENGTANG 2014-02-12 CN claimed
CN-103495172-A Medicament for treating amphetamine type stimulant dependency and mixed dependency of amphetamine type stimulants and opiates substances LU ZHENGTANG 2014-01-08 CN claimed
CN-101829328-A Medicine for treating amphetamine type stimulant dependency and mixed dependency of amphetamine type stimulant dependency and opium ZHENGTANG LU 2010-09-15 CN claimed
CN-101804197-A Medicament compound for treating cancer bone metastasis and purposes thereof HUA WEI 2010-08-18 CN claimed
CN-101277684-A Microparticles for the modified release of at least one active principle and oral pharmaceutical forms containing them FLAMEL TECH SA (FR) 2008-10-01 CN claimed
CN-1267087-C Pharmaceutical tablet PHARMACIA CORP (US) 2006-08-02 CN claimed
CN-1259974-C Drug giving-up medicine made-up by non-thebaica medicines YONG WEICHANG (CN) 2006-06-21 CN claimed
CN-1630512-A Pharmaceutical tablet PHARMACIA CORP (US) 2005-06-22 CN claimed
CN-1579551-A Drug giving-up medicine made-up by non-thebaica medicines YONG WEICHANG (CN) 2005-02-16 CN claimed
CN-1160071-C Use of substituted 2,4-imidazolidinedione compounds as analgesics 2004-08-04 CN claimed
EP-1144369-B1 ACETYLENIC ARYL SULFONAMIDE AND PHOSPHINIC ACID AMIDE HYDROXAMIC ACID TACE INHIBITORS WYETH CORP (US) 2004-07-21 EP claimed
CN-1157201-C Composite non-opium medicine for dropping drugs 卢正堂 2004-07-14 CN claimed
US-6762178-B2 FOR USE IN TREATMENT OF DISEASE CONDITIONS MEDIATED BY TNF-ALPHA, SUCH AS RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, SEPSIS, AIDS, ULCERATIVE COLITIS, MULTIPLE SCLEROSIS, CROHN'S DISEASE, DEGENERATIVE CARTILAGE LOSS WYETH HOLDINGS CORPORATION 2004-07-13 US claimed
US-20010056088-A1 Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors AMERICAN CYANAMID COMPANY (US) 2001-12-27 US claimed
EP-1144369-A2 ACETYLENIC ARYL SULFONAMIDE AND PHOSPHINIC ACID AMIDE HYDROXAMIC ACID TACE INHIBITORS American Cyanamid Company (US) 2001-10-17 EP claimed
CN-1313108-A Composite non-opium medicine for dropping drugs LU ZHENGTANG (CN) 2001-09-19 CN claimed
CN-1294519-A Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient INPHARMA SA (CH) 2001-05-09 CN claimed
WO-2000044710-A2 ACETYLENIC ARYL SULFONAMIDE AND PHOSPHINIC ACID AMIDE HYDROXAMIC ACID TACE INHIBITORS AMERICAN CYANAMID COMPANY (US) 2000-08-03 WO claimed
CN-1083383-A Analgesic health-care plaster for external use and compound method thereof HAICHENG CITY INST OF APPLIED (CN) 1994-03-09 CN claimed
US-4318909-A Benzoxazocines JOHN WYETH & BROTHER LIMITED (GB) 1982-03-09 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010056088-A1 Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors PTDSS1, SAT1, TNF MAOA 2367/4885MAOB 3438/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.