Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | ACACA | Q13085 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MGAM | O43451 | 1/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14273081 | 0.86 | PTPN7 (0.63) | RAB9AACACAKDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL5266847 | 0.81 | MGAM (0.51) | RAB9AKDM4EKMT2ASMN1; SMN2MGAM | |
| SCHEMBL159056 | 0.80 | ALDH1A1 (0.56) | RAB9AACACAKDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL1478177 | 0.78 | PTPN7 (0.71) | RAB9AKMT2APTPN7NPSR1LMNA | |
| SCHEMBL30439679 | 0.78 | PTPN7 (0.71) | RAB9AKMT2APTPN7NPSR1LMNA | |
| SCHEMBL2345799 | 0.76 | MGAM (0.57) | RAB9AKDM4EKMT2ASMN1; SMN2MGAM | |
| SCHEMBL13302131 | 0.75 | RAB9A (0.55) | RAB9AKDM4EKMT2ASMN1; SMN2MGAM | |
| SCHEMBL272613 | 0.75 | PDGFRB (0.51) | RAB9AKDM4EKMT2ASMN1; SMN2MGAM | |
| SCHEMBL28286268 | 0.75 | PDGFRB (0.51) | RAB9AKDM4EKMT2ASMN1; SMN2MGAM | |
| SCHEMBL28028944 | 0.75 | PDGFRB (0.51) | RAB9AKDM4EKMT2ASMN1; SMN2MGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6743794-B2 | MULTIDRUG RESISTANCE PROTEIN; CANCER; 3-(9-CHLORO-3-METHYL-4-OXO-5H-ISOXAZOLO(4,3-C)QUINOLIN-5-YL)) CYCLOHEXYL)-2-PIPERIDYLACETAMIDE | ELI LILLY AND COMPANY | 2004-06-01 | — | — | US | disclosed |