Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 9/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6807497 | 0.85 | F7 (0.43) | PARP1 | |
| SCHEMBL6805081 | 0.82 | PARP1 (0.48) | PARP1MEN1KMT2AMAPTLMNA | |
| SCHEMBL6802028 | 0.82 | PARP1 (0.66) | PARP1PIM1PIM3 | |
| SCHEMBL6810200 | 0.81 | ASH1L (0.54) | ALDH1A1PARP1LMNASMN1; SMN2KDM4E | |
| SCHEMBL17048129 | 0.80 | KDM4E (0.56) | ALDH1A1PARP1KMT2ACYP3A4SMN1; SMN2 | |
| SCHEMBL14091304 | 0.78 | SMN1; SMN2 (0.54) | FGFR1FGFR2ALDH1A1ATMFGFR3 | |
| SCHEMBL27461815 | 0.78 | KDM4E (0.54) | FGFR1ALDH1A1PARP1MAPTSMN1; SMN2 | |
| SCHEMBL6806330 | 0.77 | MEN1 (0.60) | FGFR1ALDH1A1PARP1MEN1KMT2A | |
| SCHEMBL6028912 | 0.77 | ALDH1A1 (0.51) | FGFR1FGFR2ALDH1A1ATMPDE10A | |
| SCHEMBL3579908 | 0.76 | PARP1 (0.61) | ALDH1A1PARP1SMN1; SMN2KDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |