SCHEMBL17048129

SCHEMBL17048129

NC(=O)c1cccc2nc(-c3nc4ccccc4[nH]3)[nH]c12

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.56
RAB9A P51151 4/20 0.56
ALDH1A1 P00352 3/20 0.56
NPC1 O15118 3/20 0.56
SMN1; SMN2 Q16637 2/20 0.56
ABCB11 O95342 1/20 0.56
TP53 P04637 1/20 0.56
PKM P14618 1/20 0.56
NPSR1 Q6W5P4 1/20 0.56
HSD17B10 Q99714 1/20 0.56
PARP1 P09874 7/20 0.52
DHODH Q02127 1/20 0.50
F2 P00734 1/20 0.49
F10 P00742 1/20 0.49
F7 P08709 1/20 0.49
HPGD P15428 2/20 0.48
BTK Q06187 1/20 0.48
CHEK1 O14757 1/20 0.47
PLK4 O00444 1/20 0.47
MAPK13 O15264 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3579908 0.84 PARP1 (0.61) KDM4ERAB9AALDH1A1NPC1SMN1; SMN2
SCHEMBL3698974 0.82 RAB9A (0.75) KDM4ERAB9AALDH1A1NPC1SMN1; SMN2
SCHEMBL30412663 0.82 RAB9A (0.75) KDM4ERAB9AALDH1A1NPC1SMN1; SMN2
SCHEMBL6802033 0.80 FGFR1 (0.51) KDM4ERAB9AALDH1A1SMN1; SMN2NPSR1
SCHEMBL17372933 0.80 RAB9A (0.63) KDM4ERAB9AALDH1A1NPC1SMN1; SMN2
SCHEMBL6806330 0.79 MEN1 (0.60) KDM4EALDH1A1NPSR1HSD17B10PARP1
SCHEMBL6805509 0.79 PARP1 (0.53) KDM4ERAB9AALDH1A1NPC1SMN1; SMN2
SCHEMBL28978359 0.79 SMN1; SMN2 (0.64) KDM4ERAB9AALDH1A1NPC1SMN1; SMN2
SCHEMBL30335387 0.79 SMN1; SMN2 (0.64) KDM4ERAB9AALDH1A1NPC1SMN1; SMN2
SCHEMBL6809996 0.78 PKN1 (0.63) KDM4EALDH1A1HSD17B10PARP1DHODH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3110803-B1 HETEROAROMATIC DERIVATIVES AND THEIR USE AS PHARMACEUTICALS MUTABILIS (FR) 2018-07-11 EP claimed
EP-3110803-B1 HETEROAROMATIC DERIVATIVES AND THEIR USE AS PHARMACEUTICALS MUTABILIS (FR) 2018-07-11 EP disclosed
EP-3110803-A1 HETEROAROMATIC DERIVATIVES AND THEIR USE AS PHARMACEUTICALS Mutabilis (FR) 2017-01-04 EP disclosed
WO-2015128333-A1 HETEROAROMATIC DERIVATIVES AND THEIR USE AS PHARMACEUTICALS LABORATOIRE BIODIM (FR) 2015-09-03 WO disclosed