SCHEMBL6803322

SCHEMBL6803322

Nc1c(Cl)cc(NS(=O)(=O)c2ccccc2)c(O)c1Cl

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 5/20 0.60
ALOX15 P16050 3/20 0.60
HSD17B10 Q99714 3/20 0.60
ALDH1A1 P00352 3/20 0.60
MEN1 O00255 3/20 0.60
KMT2A Q03164 3/20 0.60
HPGD P15428 1/20 0.60
TSHR P16473 3/20 0.56
HSP90AA1 P07900 2/20 0.54
ERBB2 P04626 1/20 0.54
HSP90AB1 P08238 1/20 0.54
EP300 Q09472 1/20 0.53
HTT P42858 2/20 0.50
PKM P14618 1/20 0.50
PGAM1 P18669 2/20 0.49
GFER P55789 1/20 0.48
APOBEC3G Q9HC16 1/20 0.48
CRHBP P24387 1/20 0.46
CRHR2 Q13324 1/20 0.46
KDM4E B2RXH2 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6806783 0.83 GAA (0.72) GAAALOX15HSD17B10ALDH1A1MEN1
SCHEMBL7702173 0.81 GAA (0.69) GAAALOX15HSD17B10ALDH1A1MEN1
SCHEMBL13510376 0.79 EP300 (0.80) GAAALOX15HSD17B10ALDH1A1MEN1
SCHEMBL5694590 0.79 ERBB2 (0.59) GAAALOX15HSD17B10ALDH1A1MEN1
SCHEMBL1913762 0.78 ERBB2 (0.62) GAAALOX15HSD17B10ALDH1A1MEN1
SCHEMBL6807579 0.78 HSD17B10 (0.57) GAAALOX15HSD17B10ALDH1A1MEN1
SCHEMBL29978640 0.77 HSD17B2 (0.67) GAAALOX15HSD17B10ALDH1A1MEN1
SCHEMBL6806504 0.77 PIK3CD (0.41) GAAALOX15HSD17B10ALDH1A1MEN1
SCHEMBL10619794 0.77 GAA (0.82) GAAALOX15HSD17B10ALDH1A1MEN1
SCHEMBL1151730 0.76 ERBB2 (0.59) GAAALOX15HSD17B10ALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6733540-B2 FOR USE IN OXIDATION DYEING OF KERATINOUS FIBRES L'OREAL (FR) 2004-05-11 US claimed
US-20020100125-A1 Use of 2-(sulphonylamino) phenols as couplers in oxidation colouring L'OREAL (FR) 2002-08-01 US claimed
EP-1205176-A1 Use of 2-sulphonylaminophenols as coupling agents in oxidation dyeing L'OREAL (FR) 2002-05-15 EP claimed
US-6733540-B2 FOR USE IN OXIDATION DYEING OF KERATINOUS FIBRES L'OREAL (FR) 2004-05-11 US disclosed
US-20020100125-A1 Use of 2-(sulphonylamino) phenols as couplers in oxidation colouring L'OREAL (FR) 2002-08-01 US disclosed
EP-1205176-A1 Use of 2-sulphonylaminophenols as coupling agents in oxidation dyeing L'OREAL (FR) 2002-05-15 EP disclosed