Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | GPR6 | P46095 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.35 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6359494 | 0.88 | KDM4E (0.55) | KDM4ESMN1; SMN2ALDH1A1CYP2D6GPR6 | |
| SCHEMBL3964348 | 0.76 | KDM4E (0.51) | RORCKDM4ESMN1; SMN2PDE2AALDH1A1 | |
| SCHEMBL6796135 | 0.73 | KDM4E (0.71) | KDM4ESMN1; SMN2PDE2AALDH1A1SIGMAR1 | |
| SCHEMBL6356329 | 0.73 | DRD4 (0.46) | SMN1; SMN2PDE2AALDH1A1SIGMAR1 | |
| SCHEMBL21794075 | 0.71 | KDM4E (0.74) | KDM4ESMN1; SMN2PDE2AALDH1A1DPP4 | |
| SCHEMBL30596583 | 0.71 | KDM4E (0.74) | KDM4ESMN1; SMN2PDE2AALDH1A1DPP4 | |
| SCHEMBL23179558 | 0.70 | ACHE (0.51) | KDM4ESMN1; SMN2PDE2AALDH1A1DRD2 | |
| SCHEMBL6947670 | 0.70 | KDM4E (0.49) | KDM4ESMN1; SMN2ALDH1A1CYP2D6SIGMAR1 | |
| SCHEMBL8109203 | 0.70 | KDM4E (0.49) | KDM4ESMN1; SMN2ALDH1A1CYP2D6SIGMAR1 | |
| SCHEMBL18712999 | 0.69 | KDM4E (0.51) | KDM4ESMN1; SMN2ALDH1A1CYP2D6SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6821964-B2 | FOR PROPHYLAXIS AND THERAPY OF DISEASES ASSOCIATED WITH MONOCYTE ACCUMULATION, LYMPHOCYTE ACCUMULATION OR LEUCOCYTE ACCUMULATION | PFIZER INC | 2004-11-23 | — | — | US | disclosed |