Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | BACE1 | P56817 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.39 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.38 |
| ▸ | PDE9A | O76083 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | AGXT | P21549 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | GPR6 | P46095 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6803418 | 0.88 | RORC (0.41) | KDM4ESMN1; SMN2ALDH1A1CYP2D6GPR6 | |
| SCHEMBL3962616 | 0.76 | KDM4E (0.70) | KDM4ESMN1; SMN2BCHEACHEBACE1 | |
| SCHEMBL19625647 | 0.75 | KDM4E (0.55) | KDM4ESMN1; SMN2BCHEACHEBACE1 | |
| SCHEMBL6356897 | 0.74 | HDAC1 (0.47) | KDM4ESMN1; SMN2BCHEACHEBACE1 | |
| SCHEMBL16731628 | 0.73 | KDM4E (0.89) | KDM4ESMN1; SMN2BCHEACHEBACE1 | |
| SCHEMBL6792953 | 0.73 | KDM4E (0.96) | KDM4ESMN1; SMN2BCHEACHEBACE1 | |
| SCHEMBL6358888 | 0.73 | KDM4E (0.46) | KDM4ESMN1; SMN2BCHEACHEBACE1 | |
| SCHEMBL6355947 | 0.72 | GRIN2B (0.41) | SMN1; SMN2ALDH1A1TDP1GRIN2B | |
| SCHEMBL30341003 | 0.71 | KDM4E (1.00) | KDM4ESMN1; SMN2BCHEACHEBACE1 | |
| SCHEMBL6927984 | 0.70 | KDM4E (0.62) | KDM4ESMN1; SMN2BCHEACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050234090-A1 | Modulators of chemokine receptor activity | PFIZER INC | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234090-A1 | Modulators of chemokine receptor activity | CCR3, CCR2, CCR1 | KDM4E 4766/4885SMN1; SMN2 3260/4885BCHE 3058/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.