Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 2/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.35 |
| ▸ | MTOR | P42345 | 4/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | YES1 | P07947 | 1/20 | 0.33 |
| ▸ | FGR | P09769 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5889155 | 0.84 | GPR119 (0.53) | GPR119TBK1TGFBR1 | |
| SCHEMBL5190202 | 0.78 | FGFR3 (0.47) | ACACBTBK1ABL1FYNYES1 | |
| SCHEMBL27769104 | 0.77 | TBK1 (0.39) | ACACBTBK1SRCJAK2JAK1 | |
| SCHEMBL5188838 | 0.77 | TBK1 (0.36) | GRIN2BACACBGPR119TBK1S1PR1 | |
| SCHEMBL27769024 | 0.77 | TBK1 (0.39) | ACACBGPR119TBK1 | |
| SCHEMBL1071028 | 0.76 | LMNA (0.41) | GPR119TBK1S1PR1 | |
| SCHEMBL27755042 | 0.76 | GPR119 (0.39) | GRIN2BACACBGPR119TBK1S1PR1 | |
| SCHEMBL27734704 | 0.76 | TBK1 (0.35) | GRIN2BACACBGPR119TBK1S1PR1 | |
| SCHEMBL1072184 | 0.75 | GPR119 (0.38) | ACACBGPR119TBK1CSF1RABL1 | |
| SCHEMBL27755006 | 0.75 | TBK1 (0.36) | ACACBGPR119TBK1CSF1RABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040063720-A1 | Tyrosine kinase inhibitors | MERCK & CO., INC. | 2004-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063720-A1 | Tyrosine kinase inhibitors | ERBB2, TYRO3, TIE1 | GRIN2B 3364/4885ACACB 1242/4885GPR119 316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.