Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 5/20 | 0.47 |
| ▸ | PARP1 | P09874 | 3/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | LTK | P29376 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6807217 | 0.85 | JAK3 (0.42) | EPHX2BTKPARP1PLK4CHEK1 | |
| SCHEMBL10267396 | 0.83 | EPHX2 (0.50) | EPHX2GRM2PARP1CHEK1MAP4K4 | |
| SCHEMBL6806401 | 0.82 | GRM2 (0.52) | EPHX2GRM2BTKPARP1PLK4 | |
| SCHEMBL6803959 | 0.81 | PARP1 (0.65) | PARP1PLK4MAP4K4PRKXROCK1 | |
| SCHEMBL6804734 | 0.80 | GRM2 (0.42) | GRM2BTKPARP1PLK4CHEK1 | |
| SCHEMBL6810614 | 0.80 | MAP4K4 (0.52) | GRM2BTKPARP1PLK4CHEK1 | |
| SCHEMBL3579908 | 0.79 | PARP1 (0.61) | PARP1PLK4MAP4K4PRKXROCK1 | |
| SCHEMBL21008512 | 0.78 | BTK (0.57) | GRM2BTKSYKLCKPLK4 | |
| SCHEMBL6805361 | 0.77 | PDPK1 (0.43) | BTKPARP1PLK4CHEK1AURKA | |
| SCHEMBL3587289 | 0.77 | AURKA (0.56) | PARP1CHEK1AURKAJAK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |