Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 12/20 | 0.42 |
| ▸ | JAK2 | O60674 | 11/20 | 0.42 |
| ▸ | JAK1 | P23458 | 10/20 | 0.42 |
| ▸ | TYK2 | P29597 | 7/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | PRKX | P51817 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6803965 | 0.85 | EPHX2 (0.55) | JAK3JAK2PLK4CHEK1AURKA | |
| SCHEMBL6807214 | 0.82 | PARP1 (0.60) | PLK4MAP4K4PRKXROCK1CLK4 | |
| SCHEMBL6806674 | 0.81 | PARP1 (0.39) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| SCHEMBL6806401 | 0.80 | GRM2 (0.52) | TYK2PLK4CHEK1AURKADAPK3 | |
| SCHEMBL6810614 | 0.77 | MAP4K4 (0.52) | TYK2PLK4CHEK1AURKADAPK3 | |
| SCHEMBL6804734 | 0.77 | GRM2 (0.42) | TYK2PLK4CHEK1AURKADAPK3 | |
| SCHEMBL3579908 | 0.76 | PARP1 (0.61) | PLK4MAP4K4PRKXROCK1CLK4 | |
| SCHEMBL6809996 | 0.74 | PKN1 (0.63) | PLK4MAP4K4PRKXROCK1CLK4 | |
| SCHEMBL2149454 | 0.74 | PARP1 (0.63) | PLK4MAP4K4PRKXROCK1CLK4 | |
| SCHEMBL29696369 | 0.73 | NPC1 (0.53) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |