Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 2/20 | 0.36 |
| ▸ | PRKX | P51817 | 2/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6806401 | 0.90 | GRM2 (0.52) | GRM2NR2E3MAP4K4ADORA2AADORA2B | |
| SCHEMBL6810614 | 0.89 | MAP4K4 (0.52) | GRM2NR2E3MAP4K4ADORA2AADORA2B | |
| SCHEMBL6804729 | 0.83 | PARP1 (0.57) | MAP4K4PLK4PRKXROCK1CLK4 | |
| SCHEMBL6801835 | 0.82 | AURKB (0.44) | MAP4K4PLK4PRKXROCK1CLK4 | |
| SCHEMBL6803965 | 0.80 | EPHX2 (0.55) | GRM2MAP4K4PLK4PRKXROCK1 | |
| SCHEMBL6807217 | 0.77 | JAK3 (0.42) | MAP4K4TYK2PLK4PRKXROCK1 | |
| SCHEMBL3579908 | 0.74 | PARP1 (0.61) | MAP4K4PLK4PRKXROCK1CLK4 | |
| SCHEMBL6806394 | 0.73 | PARP1 (0.67) | MAP4K4PLK4PRKXROCK1CLK4 | |
| SCHEMBL6810606 | 0.72 | PARP1 (0.69) | MAP4K4PLK4PRKXROCK1CLK4 | |
| SCHEMBL6586796 | 0.72 | PKN1 (0.39) | NR2E3MAP4K4PLK4PRKXROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |