Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.60 |
| ▸ | BCR | P11274 | 2/20 | 0.60 |
| ▸ | SRC | P12931 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | GFER | P55789 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | EGFR | P00533 | 2/20 | 0.57 |
| ▸ | PRKACA | P17612 | 1/20 | 0.57 |
| ▸ | PRKACG | P22612 | 1/20 | 0.57 |
| ▸ | PRKACB | P22694 | 1/20 | 0.57 |
| ▸ | SYK | P43405 | 3/20 | 0.57 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.54 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.52 |
| ▸ | CDK4 | P11802 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24270328 | 0.85 | SYK (0.62) | ABL1BCRSRCMEN1LMNA | |
| SCHEMBL11795454 | 0.83 | MEN1 (0.63) | ABL1BCRSRCMEN1LMNA | |
| SCHEMBL31302305 | 0.83 | MEN1 (0.63) | ABL1BCRSRCMEN1LMNA | |
| SCHEMBL653992 | 0.83 | SYK (0.68) | ABL1BCRSRCMEN1LMNA | |
| SCHEMBL5504084 | 0.82 | SYK (0.59) | ABL1BCRSRCMEN1LMNA | |
| SCHEMBL24507552 | 0.81 | ABL1 (0.62) | ABL1BCRSRCMEN1LMNA | |
| SCHEMBL11584735 | 0.81 | SYK (0.62) | ABL1BCRSRCMEN1LMNA | |
| SCHEMBL6804491 | 0.80 | CA12 (0.51) | ABL1BCRSRCMEN1LMNA | |
| SCHEMBL2127990 | 0.80 | MAPT (0.86) | ABL1BCRSRCMEN1LMNA | |
| SCHEMBL4903508 | 0.80 | ABL1 (0.67) | ABL1BCRSRCMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3483155-B1 | SPIRO THREE-MEMBERED RING OR SPIRO FIVE-MEMBERED RING PEPTIDE DEFORMYLASE INHIBITOR AND USE THEREOF AS AN ANTI-TUMOUR AGENT | GUANGDONG HEBO PHARMACEUTICAL CO LTD (CN) | 2022-10-26 | — | — | EP | disclosed |
| US-10738028-B2 | Spiro three-membered ring, spiro five-membered ring peptide deformylase inhibitor and use thereof in antibacteria and anti-tumor | RUDONG RUIEN PHARMACEUTICAL TECHNOLOGY CO. LTD (CN) | 2020-08-11 | — | — | US | disclosed |
| US-10738028-B2 | Spiro three-membered ring, spiro five-membered ring peptide deformylase inhibitor and use thereof in antibacteria and anti-tumor | RUDONG RUIEN PHARMACEUTICAL TECHNOLOGY CO. LTD (CN) | 2020-08-11 | — | — | US | disclosed |
| CN-107362162-B | Antitumor application of spirotricyclic and spiropentacyclic peptide deformylase inhibitor | 如东瑞恩医药科技有限公司 | 2019-12-13 | — | — | CN | disclosed |
| CN-107365303-B | Antibacterial application of spirotricyclic and spiropentacyclic peptide deformylase inhibitor | 如东瑞恩医药科技有限公司 | 2019-12-13 | — | — | CN | disclosed |
| CN-107365302-B | Spiro three-membered ring, spirofive-membered ring peptoid deformylase inhibitors | 如东瑞恩医药科技有限公司 | 2019-12-13 | — | — | CN | disclosed |
| US-20190194165-A1 | SPIRO THREE-MEMBERED RING, SPIRO FIVE-MEMBERED RING PEPTIDE DEFORMYLASE INHIBITOR AND USE THEREOF IN ANTIBACTERIA AND ANTI-TUMOR | RUDONG RUIEN PHARMACEUTICAL TECHNOLOGY CO. LTD (CN) | 2019-06-27 | — | — | US | disclosed |
| US-20190194165-A1 | SPIRO THREE-MEMBERED RING, SPIRO FIVE-MEMBERED RING PEPTIDE DEFORMYLASE INHIBITOR AND USE THEREOF IN ANTIBACTERIA AND ANTI-TUMOR | RUDONG RUIEN PHARMACEUTICAL TECHNOLOGY CO. LTD (CN) | 2019-06-27 | — | — | US | disclosed |
| EP-3483155-A1 | SPIRO THREE-MEMBERED RING, SPIRO FIVE-MEMBERED RING PEPTIDE DEFORMYLASE INHIBITOR AND USE THEREOF IN ANTIBACTERIA AND ANTI-TUMOUR. | Rudong Ruien Pharmaceutical Technology Co., Ltd. (CN) | 2019-05-15 | — | — | EP | disclosed |
| EP-3483155-A1 | SPIRO THREE-MEMBERED RING, SPIRO FIVE-MEMBERED RING PEPTIDE DEFORMYLASE INHIBITOR AND USE THEREOF IN ANTIBACTERIA AND ANTI-TUMOUR. | Rudong Ruien Pharmaceutical Technology Co., Ltd. (CN) | 2019-05-15 | — | — | EP | disclosed |
| WO-2017193924-A1 | SPIRO THREE-MEMBERED RING, SPIRO FIVE-MEMBERED RING PEPTIDE DEFORMYLASE INHIBITOR AND USE THEREOF IN ANTIBACTERIA AND ANTI-TUMOUR. | 如东瑞恩医药科技有限公司 | 2017-11-16 | — | — | WO | disclosed |
| US-6727245-B2 | 4-(HETERO)ARYL-3-OXO-3,4-DIHYDROPYRIDO(2,3-B)PYRAZINE DERIVATIVES; PROPHYLACTIC OR THERAPEUTIC TREATMENT OF PHOSPHODIESTERASE IV AND TUMOR NECROSIS FACTOR MEDIATED DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-04-27 | — | — | US | disclosed |
| EP-0770079-B1 | HETEROBICYCLIC DERIVATIVES | FUJISAWA PHARMACEUTICAL CO (JP) | 2003-02-12 | — | — | EP | disclosed |
| US-20020107251-A1 | Heterobicyclic derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-08-08 | — | — | US | disclosed |
| US-6426345-B1 | PHOSPHODIESTERASE INHIBITORS; ANTIINFLAMMATORY AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-07-30 | — | — | US | disclosed |
| EP-0920867-A1 | Pyrido[2,3-a]pyrazine derivatives as PDE-IV and TNF inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-06-09 | — | — | EP | disclosed |
| WO-1996001825-A1 | HETEROBICYCLIC DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10738028-B2 | Spiro three-membered ring, spiro five-membered ring peptide deformylase inhibitor and use thereof in antibacteria and anti-tumor | PDF, HSPE1, ERAL1 | ABL1 4483/4885BCR 50/4885SRC 3665/4885 |
| US-20190194165-A1 | SPIRO THREE-MEMBERED RING, SPIRO FIVE-MEMBERED RING PEPTIDE DEFORMYLASE INHIBITOR AND USE THEREOF IN ANTIBACTERIA AND ANTI-TUMOR | PDF, HSPE1, ATP5PB | ABL1 4580/4885BCR 55/4885SRC 3771/4885 |
| US-20020107251-A1 | Heterobicyclic derivatives | ARSA, ARRB1, SULT2A1 | ABL1 408/4885BCR 1628/4885SRC 232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.