Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 18/20 | 0.59 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.59 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.46 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6587344 | 0.88 | PARP1 (0.43) | PARP1PLA2G2AALOX15PTGS2 | |
| SCHEMBL6804463 | 0.85 | FLT3 (0.42) | PARP1PLA2G2AALOX15PTGS2CHEK2 | |
| SCHEMBL6802778 | 0.80 | PARP1 (0.61) | PARP1CHEK2PKN1PKN2 | |
| SCHEMBL6807418 | 0.78 | PARP1 (0.53) | PARP1CHEK2PKN1PKN2 | |
| SCHEMBL6807472 | 0.77 | PARP1 (0.56) | PARP1PLA2G2AALOX15PTGS2CHEK2 | |
| SCHEMBL7319077 | 0.76 | PARP1 (1.00) | PARP1PLA2G2AALOX15PTGS2CHEK2 | |
| SCHEMBL6810588 | 0.76 | PARP1 (0.58) | PARP1CHEK2PKN1PKN2 | |
| SCHEMBL6806910 | 0.75 | PARP1 (0.60) | PARP1PLA2G2AALOX15PTGS2CHEK2 | |
| SCHEMBL6804961 | 0.73 | PARP1 (0.72) | PARP1PLA2G2AALOX15PTGS2CHEK2 | |
| SCHEMBL28451458 | 0.71 | STK33 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |