Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | SI | P14410 | 2/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.38 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6804455 | 0.88 | PARP1 (0.59) | PARP1PLA2G2AALOX15PTGS2 | |
| SCHEMBL6587124 | 0.81 | PARP1 (0.43) | PARP1FLT3MGAMGAASI | |
| SCHEMBL6589144 | 0.80 | PARP1 (0.42) | PARP1PLA2G2AALOX15PTGS2MGAM | |
| SCHEMBL6587656 | 0.79 | PARP1 (0.38) | PARP1FLT3DHODH | |
| SCHEMBL6587520 | 0.78 | PARP1 (0.46) | PARP1PTGS2MGAMGAASI | |
| SCHEMBL6585205 | 0.77 | PARP1 (0.42) | PARP1PLA2G2AALOX15PTGS2MGAM | |
| SCHEMBL6804463 | 0.77 | FLT3 (0.42) | PARP1PLA2G2AALOX15PTGS2FLT3 | |
| SCHEMBL6586096 | 0.74 | PARP1 (0.53) | PARP1PLA2G2AALOX15PTGS2FLT3 | |
| SCHEMBL6585146 | 0.71 | PARP1 (0.47) | PARP1PLA2G2AALOX15PTGS2MGAM | |
| SCHEMBL6587758 | 0.71 | PARP1 (0.57) | PARP1PLA2G2AALOX15PTGS2HPSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-B1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | ABBOTT GMBH & CO KG (DE) | 2004-12-29 | — | — | EP | disclosed |
| WO-2001082877-A2 | USE OF PARP INHIBITORS IN COSMETIC PREPARATIONS | BASF AKTIENGESELLSCHAFT (DE) | 2001-11-08 | — | — | WO | disclosed |