Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 7/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6804455 | 0.85 | PARP1 (0.59) | PARP1PLA2G2AALOX15PTGS2CHEK2 | |
| SCHEMBL6802788 | 0.80 | PARP1 (0.41) | FLT3PARP1 | |
| SCHEMBL6807422 | 0.78 | MALT1 (0.39) | FLT3PARP1ALDH1A1 | |
| SCHEMBL6807476 | 0.77 | GRM2 (0.44) | FLT3PARP1PTGS2MAPK14NPC1 | |
| SCHEMBL6587344 | 0.77 | PARP1 (0.43) | FLT3MAPKAPK2PARP1PLA2G2AALOX15 | |
| SCHEMBL6810590 | 0.76 | GRM2 (0.54) | PARP1PTGS2NPC1RAB9AMAPT | |
| SCHEMBL6806912 | 0.75 | GRM2 (0.44) | PARP1PTGS2MEN1KMT2ANPC1 | |
| SCHEMBL6804968 | 0.73 | PARP1 (0.49) | PARP1PLA2G2AALOX15PTGS2NPC1 | |
| SCHEMBL28451458 | 0.71 | STK33 (0.49) | FLT3MEN1KMT2ANPC1RAB9A | |
| SCHEMBL8648025 | 0.70 | PARP1 (0.67) | PARP1L3MBTL1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |