Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | GALR3 | O60755 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PRF1 | P14222 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4313188 | 0.88 | PIN1 (0.46) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL19946295 | 0.81 | KDM4E (0.55) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL31686363 | 0.80 | AKR1C3 (0.44) | HTTMEN1KMT2A | |
| SCHEMBL6535444 | 0.79 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL20568185 | 0.77 | ALDH1A1 (0.46) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL3528049 | 0.74 | ALDH1A1 (0.61) | KDM4EGAAALDH1A1HPGDLMNA | |
| SCHEMBL19946214 | 0.74 | MET (0.53) | KDM4EGAAALDH1A1HPGDLMNA | |
| SCHEMBL3504485 | 0.74 | PDE3B (0.56) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7276070 | 0.73 | PDE3B (0.61) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL6029149 | 0.73 | TDP1 (0.43) | KDM4EGAAALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154944-B1 | SUBSTITUTED PYRIDINONES AS MGAT2 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-14 | — | — | EP | disclosed |
| EP-2310382-B1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | LILLY CO ELI (US) | 2012-02-22 | — | — | EP | disclosed |