Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 10/20 | 0.46 |
| ▸ | NPC1 | O15118 | 9/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | GAPDH | P04406 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6641956 | 0.83 | HTR1F (0.81) | HTR1FRAB9ANPC1LMNAKMT2A | |
| Oxalic Acid SCHEMBL6799756 | 0.82 | NPC1 (0.47) | HTR1FRAB9ANPC1SMN1; SMN2LMNA | |
| Oxalic Acid SCHEMBL6646761 | 0.81 | HTR1F (0.65) | HTR1FRAB9ANPC1SMN1; SMN2KMT2A | |
| Oxalic Acid SCHEMBL6804728 | 0.81 | HTR1F (0.94) | HTR1FRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL6641025 | 0.79 | HTR1F (0.71) | HTR1FLMNAMAPTPOLBKDM4E | |
| Oxalic Acid SCHEMBL6644453 | 0.77 | HTR1F (0.40) | HTR1FRAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL8552436 | 0.77 | KMT2A (0.49) | RAB9ANPC1SMN1; SMN2LMNAKMT2A | |
| Oxalic Acid SCHEMBL6645100 | 0.74 | SMN1; SMN2 (0.37) | HTR1FRAB9ANPC1SMN1; SMN2LMNA | |
| Oxalic Acid SCHEMBL6644450 | 0.71 | MAPT (0.34) | HTR1FRAB9ANPC1SMN1; SMN2LMNA | |
| Oxalic Acid SCHEMBL6648004 | 0.66 | HTR1F (0.51) | HTR1FRAB9ANPC1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696439-B1 | HETEROCYCLIC IMINES SUCH AS 2-METHYL-3-(2-(N',N'-DIETHYLAMINO) ETHYL)-5-(4-PROPANESULFONYLBENZAMIDE)FURO(3,2-B)PYRIDINE, HYDROCHLORIDE, USED AS SEROTONIN RECEPTOR ANTAGONISTS FOR PROPHYLAXIS OF HEADACHES | ELI LILLY AND COMPANY | 2004-02-24 | — | — | US | disclosed |