Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.47 |
| ▸ | RAB9A | P51151 | 10/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | GAPDH | P04406 | 1/20 | 0.41 |
| ▸ | HTR1F | P30939 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | HTR1D | P28221 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL6648004 | 0.85 | HTR1F (0.51) | NPC1RAB9ASMN1; SMN2KMT2AHTR1F | |
| Oxalic Acid SCHEMBL6806129 | 0.82 | HTR1F (0.63) | NPC1RAB9ASMN1; SMN2LMNAKMT2A | |
| Oxalic Acid SCHEMBL6643189 | 0.81 | HTR1A (0.41) | RAB9ALMNAHTR1FHPGDHTR1A | |
| Oxalic Acid SCHEMBL6643017 | 0.80 | HTR1F (0.63) | NPC1RAB9AHTR1FHTR1AHTR1D | |
| SCHEMBL6647839 | 0.79 | MTNR1A (0.48) | LMNAHTR1FHPGDHTR1AHTR1D | |
| Oxalic Acid SCHEMBL6804700 | 0.77 | HTR1F (0.48) | NPC1RAB9ASMN1; SMN2LMNAHTR1F | |
| Oxalic Acid SCHEMBL6645098 | 0.70 | NOS3 (0.35) | NPC1RAB9ASMN1; SMN2KMT2AHPGD | |
| Hydrochloric Acid SCHEMBL8001822 | 0.67 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2LMNAKMT2A | |
| SCHEMBL6668691 | 0.67 | HTR1F (0.49) | NPC1RAB9ASMN1; SMN2LMNAHTR1F | |
| Hydrochloric Acid SCHEMBL5906253 | 0.66 | HTR1F (0.48) | NPC1RAB9ASMN1; SMN2LMNAHTR1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696439-B1 | HETEROCYCLIC IMINES SUCH AS 2-METHYL-3-(2-(N',N'-DIETHYLAMINO) ETHYL)-5-(4-PROPANESULFONYLBENZAMIDE)FURO(3,2-B)PYRIDINE, HYDROCHLORIDE, USED AS SEROTONIN RECEPTOR ANTAGONISTS FOR PROPHYLAXIS OF HEADACHES | ELI LILLY AND COMPANY | 2004-02-24 | — | — | US | disclosed |