Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HTR1F | P30939 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL6643021 | 0.80 | HTR1F (0.52) | SMN1; SMN2MAPTNPC1RAB9AMAPK1 | |
| Oxalic Acid SCHEMBL6644450 | 0.79 | MAPT (0.34) | SMN1; SMN2MAPTNPC1RAB9AALOX15 | |
| Oxalic Acid SCHEMBL6644453 | 0.77 | HTR1F (0.40) | SMN1; SMN2MAPTNPC1RAB9AALOX15 | |
| Oxalic Acid SCHEMBL6645098 | 0.74 | NOS3 (0.35) | SMN1; SMN2MAPTNPC1RAB9AALOX15 | |
| Oxalic Acid SCHEMBL6806129 | 0.74 | HTR1F (0.63) | SMN1; SMN2MAPTNPC1RAB9AMAPK1 | |
| Oxalic Acid SCHEMBL6799756 | 0.65 | NPC1 (0.47) | SMN1; SMN2MAPTNPC1RAB9AALOX15 | |
| SCHEMBL9868165 | 0.63 | MAPT (0.53) | SMN1; SMN2MAPTNPC1RAB9AALOX15 | |
| Oxalic Acid SCHEMBL6646761 | 0.60 | HTR1F (0.65) | SMN1; SMN2MAPTNPC1RAB9AHTR1F | |
| SCHEMBL471019 | 0.59 | ALDH1A1 (0.69) | SMN1; SMN2MAPTNPC1RAB9AMAPK1 | |
| Oxalic Acid SCHEMBL11705283 | 0.58 | HPGDS (0.47) | SMN1; SMN2MAPTNPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155020-B1 | FURO[3,2-B]PYRIDINES AS 5-HT1F AGONISTS | LILLY CO ELI (US) | 2004-02-04 | — | — | EP | disclosed |