Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 6/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.42 |
| ▸ | PARP3 | Q9Y6F1 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | PRKX | P51817 | 2/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | LTK | P29376 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6807081 | 0.83 | PARP1 (0.64) | PARP1PARP2PLK4MAP4K4PRKX | |
| SCHEMBL6806912 | 0.81 | GRM2 (0.44) | PARP1PARP2PARP3MEN1KMT2A | |
| SCHEMBL6804457 | 0.79 | PARP1 (0.42) | PARP1PARP2PARP3MEN1KMT2A | |
| SCHEMBL6810614 | 0.78 | MAP4K4 (0.52) | PARP1PARP2PARP3ADORA2BPLK4 | |
| SCHEMBL6807111 | 0.77 | PARP1 (0.46) | PARP1PARP2PARP3MEN1KMT2A | |
| SCHEMBL6810628 | 0.74 | PARP1 (0.52) | PARP1PARP2PARP3 | |
| SCHEMBL6806559 | 0.74 | SMN1; SMN2 (0.53) | PARP1PARP2PARP3KMT2ACHEK2 | |
| SCHEMBL6811163 | 0.72 | PARP1 (0.48) | PARP1CHEK2 | |
| SCHEMBL6591702 | 0.72 | PARP1 (0.44) | NR3C2PARP1PARP2MEN1KMT2A | |
| SCHEMBL6805083 | 0.72 | TSHR (0.48) | PARP1PARP2PARP3KMT2APLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |