Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 1/20 | 0.41 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.41 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 14/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5616291 | 0.81 | DHFR (0.39) | PI4KAPI4K2BPI4K2API4KBTLR8 | |
| SCHEMBL18585619 | 0.77 | TLR8 (0.52) | TLR8TLR7 | |
| SCHEMBL7253489 | 0.76 | EPHX1 (0.45) | — | |
| SCHEMBL18587553 | 0.74 | TLR8 (0.50) | PI4KAPI4K2BPI4K2API4KBTLR8 | |
| SCHEMBL9038851 | 0.73 | PARP1 (0.57) | TLR8TLR7 | |
| SCHEMBL14125777 | 0.73 | CSNK1A1 (0.43) | PI4KAPI4K2BPI4K2API4KBTLR8 | |
| SCHEMBL20134736 | 0.71 | DHFR (0.67) | DHFR | |
| SCHEMBL29871746 | 0.71 | TLR7 (0.48) | PI4KAPI4K2BPI4K2API4KBTLR8 | |
| SCHEMBL31151227 | 0.70 | TLR8 (0.51) | TLR8TLR7 | |
| SCHEMBL18109747 | 0.70 | DHFR (0.69) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6693113-B2 | 2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]napthyridin-4 amine | 3M INNOVATIVE PROPERTIES COMPANY | 2004-02-17 | — | — | US | disclosed |