SCHEMBL6807571

SCHEMBL6807571

COC(=O)Nc1cc(O)c(NS(C)(=O)=O)cc1OC

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.56
MEN1 O00255 2/20 0.56
KMT2A Q03164 2/20 0.56
SMN1; SMN2 Q16637 2/20 0.56
PKM P14618 1/20 0.43
HTT P42858 1/20 0.43
MAPK1 P28482 1/20 0.42
GAA P10253 1/20 0.40
TSHR P16473 2/20 0.39
LMNA P02545 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
ADRB3 P13945 3/20 0.39
KDM4E B2RXH2 1/20 0.38
HSD17B10 Q99714 1/20 0.38
HPGD P15428 1/20 0.38
TUBB4A P04350 1/20 0.38
TUBB P07437 1/20 0.38
TUBA3C P0DPH7 1/20 0.38
TUBA1B P68363 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6806453 0.88 ALDH1A1 (0.56) ALDH1A1MEN1KMT2ASMN1; SMN2GAA
SCHEMBL6802561 0.82 SMN1; SMN2 (0.38) ALDH1A1MEN1KMT2ASMN1; SMN2HTT
SCHEMBL6807890 0.81 KMT2A (0.54) ALDH1A1MEN1KMT2ASMN1; SMN2HTT
SCHEMBL7251834 0.78 PKM (0.47) ALDH1A1MEN1KMT2ASMN1; SMN2PKM
SCHEMBL6806745 0.78 ALDH1A1 (0.47) ALDH1A1MEN1KMT2ASMN1; SMN2MAPK1
SCHEMBL6573637 0.78 POLB (0.55) ALDH1A1MEN1KMT2ASMN1; SMN2PKM
SCHEMBL6806493 0.77 PKM (0.47) ALDH1A1MEN1KMT2ASMN1; SMN2PKM
Hydrochloric Acid SCHEMBL6574257 0.77 POLB (0.57) ALDH1A1MEN1KMT2ASMN1; SMN2PKM
SCHEMBL7251136 0.75 HTT (0.42) ALDH1A1MEN1KMT2ASMN1; SMN2PKM
SCHEMBL9198834 0.75 ALDH1A1 (0.50) ALDH1A1MEN1KMT2ASMN1; SMN2HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6733540-B2 FOR USE IN OXIDATION DYEING OF KERATINOUS FIBRES L'OREAL (FR) 2004-05-11 US claimed
US-20020100125-A1 Use of 2-(sulphonylamino) phenols as couplers in oxidation colouring L'OREAL (FR) 2002-08-01 US claimed
EP-1205176-A1 Use of 2-sulphonylaminophenols as coupling agents in oxidation dyeing L'OREAL (FR) 2002-05-15 EP claimed
US-6733540-B2 FOR USE IN OXIDATION DYEING OF KERATINOUS FIBRES L'OREAL (FR) 2004-05-11 US disclosed
US-20020100125-A1 Use of 2-(sulphonylamino) phenols as couplers in oxidation colouring L'OREAL (FR) 2002-08-01 US disclosed
EP-1205176-A1 Use of 2-sulphonylaminophenols as coupling agents in oxidation dyeing L'OREAL (FR) 2002-05-15 EP disclosed