⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3876392 | 0.95 | ATM (0.65) | — | |
| SCHEMBL3969156 | 0.93 | ATM (0.62) | — | |
| SCHEMBL6050119 | 0.86 | ATM (0.67) | — | |
| SCHEMBL6043978 | 0.81 | ATM (0.74) | — | |
| SCHEMBL1711871 | 0.79 | TDP1 (0.48) | — | |
| SCHEMBL6483244 | 0.79 | TDP1 (0.48) | — | |
| SCHEMBL295077 | 0.79 | L3MBTL1 (0.55) | — | |
| SCHEMBL6044009 | 0.79 | ALDH1A1 (0.41) | — | |
| SCHEMBL5542703 | 0.79 | CA2 (0.45) | — | |
| SCHEMBL6042389 | 0.79 | ATM (0.71) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040204367-A1 | Pipecolic acid derivatives of proline threonine amides useful for the treatment of rheumatoid arthritis | G.D. SEARLE & CO. (US) | 2004-10-14 | — | — | US | claimed |
| US-6613880-B2 | Autoimmune diseases; inflammatory conditions; competitive binding with Human Leukocyte Antigen displacing disease-inducing endogenous peptides | PHARMACIA CORPORATION | 2003-09-02 | — | — | US | claimed |
| US-20010027247-A1 | Pipecolic acid derivatives of proline threonine amides useful for the treatment of rheumatoid arthritis | G.D. SEARLE & CO., (US) | 2001-10-04 | — | — | US | claimed |
| CN-116947877-A | Benzimidazole derivative and application thereof in medicine | 四川海思科制药有限公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-116640157-A | METTL3 inhibitor and composition thereof and application of METTL3 inhibitor and composition thereof in medicine | 海思科医药集团股份有限公司 | 2023-08-25 | — | — | CN | disclosed |
| US-20040204367-A1 | Pipecolic acid derivatives of proline threonine amides useful for the treatment of rheumatoid arthritis | G.D. SEARLE & CO. (US) | 2004-10-14 | — | — | US | disclosed |
| US-6613880-B2 | Autoimmune diseases; inflammatory conditions; competitive binding with Human Leukocyte Antigen displacing disease-inducing endogenous peptides | PHARMACIA CORPORATION | 2003-09-02 | — | — | US | disclosed |
| US-20010027247-A1 | Pipecolic acid derivatives of proline threonine amides useful for the treatment of rheumatoid arthritis | G.D. SEARLE & CO., (US) | 2001-10-04 | — | — | US | disclosed |
| WO-1996040753-A1 | PIPECOLIC ACID DERIVATIVES OF PROLINE THREONINE AMIDES USEFUL FOR THE TREATMENT OF RHEUMATOID ARTHRITIS | G.D. SEARLE & CO. (US) | 1996-12-19 | — | — | WO | disclosed |