Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | XIAP | P98170 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KHK | P50053 | 2/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.35 |
| ▸ | TCF7L2 | Q9NQB0 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6808590 | 1.00 | ALDH1A1 (0.44) | ALDH1A1LMNAHTR2CHSD11B1XIAP | |
| SCHEMBL6811380 | 0.87 | HTR2C (0.44) | ALDH1A1LMNAHTR2CHSD11B1XIAP | |
| SCHEMBL6811374 | 0.87 | HTR2C (0.44) | ALDH1A1LMNAHTR2CHSD11B1XIAP | |
| SCHEMBL6811515 | 0.81 | HTR2C (0.41) | ALDH1A1LMNAHTR2CHSD11B1XIAP | |
| SCHEMBL1904404 | 0.81 | ALDH1A1 (0.60) | ALDH1A1LMNAHTR2CHSD11B1XIAP | |
| SCHEMBL14922244 | 0.79 | ALDH1A1 (0.48) | ALDH1A1LMNAHTR2CHSD11B1XIAP | |
| SCHEMBL30952471 | 0.78 | LMNA (0.47) | ALDH1A1LMNAHTR2CHSD11B1XIAP | |
| SCHEMBL21358968 | 0.78 | LMNA (0.47) | ALDH1A1LMNAHTR2CHSD11B1XIAP | |
| SCHEMBL30952442 | 0.78 | LMNA (0.47) | ALDH1A1LMNAHTR2CHSD11B1XIAP | |
| SCHEMBL21358963 | 0.78 | LMNA (0.47) | ALDH1A1LMNAHTR2CHSD11B1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040122001-A1 | Pharmaceutical compounds | ELI LILLY AND COMPANY | 2004-06-24 | — | — | US | disclosed |
| EP-1345930-A2 | PHARMACEUTICAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002050067-A2 | PHARMACEUTICAL HETEROCYCLIC COMPOUNDS | ELI LILLY AND COMPANY (US) | 2002-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040122001-A1 | Pharmaceutical compounds | CYP2D6, LPXN, CYP1B1 | ALDH1A1 1563/4885LMNA 1448/4885HTR2C 1211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.