SCHEMBL6808768

SCHEMBL6808768

O=C(CO)Cc1ccc([N+](=O)[O-])cc1

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.58
CYP2C19 P33261 2/20 0.56
CYP1A2 P05177 1/20 0.56
MAPT P10636 3/20 0.53
GAA P10253 1/20 0.53
PKM P14618 1/20 0.53
LOXL2 Q9Y4K0 1/20 0.52
ALDH1A1 P00352 4/20 0.50
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
HTT P42858 1/20 0.50
CES1 P23141 1/20 0.48
RECQL P46063 1/20 0.48
IDO1 P14902 1/20 0.47
CA1 P00915 1/20 0.47
CA2 P00918 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
KCNJ1 P48048 1/20 0.47
KCNH2 Q12809 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29158557 0.91 TSHR (0.53) TSHRCYP2C19CYP1A2MAPTGAA
SCHEMBL6932662 0.90 CYP2C19 (0.61) TSHRCYP2C19CYP1A2MAPTGAA
SCHEMBL6647402 0.85 TSHR (0.59) TSHRCYP2C19CYP1A2MAPTGAA
SCHEMBL28532343 0.83 ALDH1A1 (0.60) CYP2C19CYP1A2MAPTALDH1A1MEN1
SCHEMBL22408746 0.83 CYP2C19 (0.54) TSHRCYP2C19CYP1A2MAPTGAA
SCHEMBL12179295 0.83 CYP2C19 (0.54) TSHRCYP2C19CYP1A2MAPTGAA
SCHEMBL3014336 0.83 CYP2C19 (0.54) TSHRCYP2C19CYP1A2MAPTGAA
SCHEMBL4833266 0.83 GSK3B (0.58) TSHRCYP2C19CYP1A2MAPTGAA
SCHEMBL11373145 0.83 CYP2C19 (0.54) TSHRCYP2C19CYP1A2MAPTGAA
SCHEMBL3083250 0.82 CYP2C19 (0.57) TSHRCYP2C19CYP1A2MAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116732114-A Use of BsALS as catalyst in synthesis of o-hydroxy ketone compound and N-aryl hydroxamic acid 西北大学 2023-09-12 CN disclosed
US-20230226093-A1 ADENOSINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME BRII BIOSCIENCES, INC. 2023-07-20 US disclosed
US-6794378-B2 ANTIINFLAMMATORY AGENTS AJINOMOTO CO., INC. (JP) 2004-09-21 US disclosed
US-20020133005-A1 Heterocyclic compounds and medical use thereof AJINOMOTO CO., INC. (JP) 2002-09-19 US disclosed
EP-1193255-A1 HETEROCYCLIC COMPOUNDS AND MEDICINAL USE THEREOF Ajinomoto Co., Inc. (JP) 2002-04-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230226093-A1 ADENOSINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME ADAR, ADA, ADORA2A TSHR 4315/4885CYP2C19 585/4885CYP1A2 568/4885
US-20020133005-A1 Heterocyclic compounds and medical use thereof NFKBIA, CHUK, RELA TSHR 4622/4885CYP2C19 4099/4885CYP1A2 3947/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.