⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6809355 | 0.95 | — | — | |
| SCHEMBL6809348 | 0.90 | — | — | |
| SCHEMBL11919857 | 0.85 | — | — | |
| SCHEMBL11919868 | 0.84 | — | — | |
| SCHEMBL11919859 | 0.84 | — | — | |
| SCHEMBL16134891 | 0.83 | — | — | |
| SCHEMBL14047752 | 0.75 | — | — | |
| SCHEMBL6809307 | 0.74 | CHRM2 (0.31) | — | |
| SCHEMBL6809314 | 0.69 | OPRM1 (0.35) | — | |
| SCHEMBL11287401 | 0.68 | DNM1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9045494-B2 | Orthoester compound | NEKTAR THERAPEUTICS (US) | 2015-06-02 | — | — | US | disclosed |
| US-20140296541-A1 | ORTHOESTER COMPOUND | NEKTAR THERAPEUTICS | 2014-10-02 | — | — | US | disclosed |
| US-8784791-B2 | Method for preparing water-soluble polymer derivatives bearing an N-succinimidyl ester | NEKTAR THERAPEUTICS (US) | 2014-07-22 | — | — | US | disclosed |
| US-20130231490-A1 | METHOD FOR PREPARING WATER-SOLUBLE POLYMER DERIVATIVES BEARING AN N-SUCCINIMIDYL ESTER | NEKTAR THERAPEUTICS (US) | 2013-09-05 | — | — | US | disclosed |
| US-8435504-B2 | Method for preparing water-soluble polymer derivatives bearing a terminal carboxylic acid | NEKTAR THERAPEUTICS (US) | 2013-05-07 | — | — | US | disclosed |
| US-20120209027-A1 | Method for Preparing Water-Soluble Polymer Derivatives Bearing a Terminal Carboxylic Acid | NEKTAR THERAPEUTICS (US) | 2012-08-16 | — | — | US | disclosed |
| US-8182801-B2 | Method for preparing water-soluble polymer derivatives bearing a terminal carboxylic acid | NEKTAR THERAPEUTICS (US) | 2012-05-22 | — | — | US | disclosed |
| US-20090264600-A1 | Method for Preparing Water-Soluble Polymer Derivatives Bearing a Terminal Carboxylic Acid | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2009-10-22 | — | — | US | disclosed |
| US-7569214-B2 | Hydrolysing water-soluble polyoxyethylene glycol segment having alkoxide ion or thiolate ion with ortho ester comprised of suitable leaving group (methanesulfonate) | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2009-08-04 | — | — | US | disclosed |