Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23629459 | 0.86 | CHRNA7 (0.52) | HPGDHTTLMNARAB9ANPC1 | |
| SCHEMBL23629499 | 0.86 | KDM4E (0.50) | HPGDHTTLMNARAB9ANPC1 | |
| SCHEMBL5762071 | 0.86 | MAPK1 (0.65) | HPGDHTTLMNARAB9ANPC1 | |
| SCHEMBL3061680 | 0.86 | ALDH1A1 (0.57) | HPGDHTTRAB9AMAPK1KDM4E | |
| SCHEMBL23629430 | 0.84 | POLB (0.45) | HPGDHTTLMNARAB9ANPC1 | |
| SCHEMBL6212346 | 0.82 | MAPK1 (0.60) | HPGDHTTRAB9ANPC1CHRNA7 | |
| SCHEMBL679510 | 0.81 | NOTUM (0.60) | HPGDLMNAPOLBKDM4EL3MBTL1 | |
| SCHEMBL23146843 | 0.80 | POLB (0.52) | HPGDLMNARAB9ANPC1POLB | |
| SCHEMBL16092699 | 0.80 | POLB (0.49) | HPGDHTTLMNARAB9ANPC1 | |
| SCHEMBL14969108 | 0.80 | ALDH1A1 (0.51) | HPGDHTTLMNARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113195471-B | Polysubstituted pyridone derivative and application thereof in medicine | 苏州浦合医药科技有限公司 | 2023-05-02 | — | — | CN | disclosed |
| CN-110627796-B | Nitrogenous heterocyclic derivative and application thereof in medicine | 北京越之康泰生物医药科技有限公司 | 2022-07-12 | — | — | CN | disclosed |
| US-20210355107-A1 | MULTI-SUBSTITUTED PYRIDONE DERIVATIVES AND MEDICAL USE THEREOF | BEIJING YUEZHIKANGTAI BIOMEDICINES CO LTD (CN) | 2021-11-18 | — | — | US | disclosed |
| US-20210355107-A1 | MULTI-SUBSTITUTED PYRIDONE DERIVATIVES AND MEDICAL USE THEREOF | BEIJING YUEZHIKANGTAI BIOMEDICINES CO LTD (CN) | 2021-11-18 | — | — | US | disclosed |
| CN-113195471-A | Polysubstituted pyridone derivative and application thereof in medicine | 北京越之康泰生物医药科技有限公司 | 2021-07-30 | — | — | CN | disclosed |
| EP-3845527-A1 | MULTI-SUBSTITUTED PYRIDONE DERIVATIVES AND MEDICAL USE THEREOF | Beijing Yuezhikangtai Biomedicines Co., Ltd. (CN) | 2021-07-07 | — | — | EP | disclosed |
| EP-3845527-A1 | MULTI-SUBSTITUTED PYRIDONE DERIVATIVES AND MEDICAL USE THEREOF | Beijing Yuezhikangtai Biomedicines Co., Ltd. (CN) | 2021-07-07 | — | — | EP | disclosed |
| WO-2020042618-A1 | MULTI-SUBSTITUTED PYRIDONE DERIVATIVES AND MEDICAL USE THEREOF | 北京越之康泰生物医药科技有限公司 | 2020-03-05 | — | — | WO | disclosed |
| WO-2020042618-A1 | MULTI-SUBSTITUTED PYRIDONE DERIVATIVES AND MEDICAL USE THEREOF | 北京越之康泰生物医药科技有限公司 | 2020-03-05 | — | — | WO | disclosed |
| CN-110627796-A | Nitrogenous heterocyclic derivative and application thereof in medicine | 北京越之康泰生物医药科技有限公司 | 2019-12-31 | — | — | CN | disclosed |
| US-RE43878-E1 | Amidophenoxyindazoles useful as inhibitors of c-Met | ELI LILLY AND COMPANY (US) | 2012-12-25 | — | — | US | disclosed |
| EP-2310382-B1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | LILLY CO ELI (US) | 2012-02-22 | — | — | EP | disclosed |
| US-8030302-B2 | Amidophenoxyindazoles useful as inhibitors of c-Met | ELI LILLY AND COMPANY (US) | 2011-10-04 | — | — | US | disclosed |
| US-20100022529-A1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | ELI LILLY AND COMPANY | 2010-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210355107-A1 | MULTI-SUBSTITUTED PYRIDONE DERIVATIVES AND MEDICAL USE THEREOF | PDXK, ITK, JAK1 | HPGD 577/4885HTT 3897/4885LMNA 3969/4885 |
| US-20100022529-A1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | MET, MYCBP, MYC | HPGD 3623/4885HTT 4635/4885LMNA 4448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.