Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.39 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6805803 | 0.99 | PARP1 (0.49) | PARP1CHEK2DHODHHTR1AALDH1A1 | |
| SCHEMBL6806306 | 0.95 | PARP1 (0.47) | PARP1CHEK2DHODHHTR1AKDM4E | |
| SCHEMBL6810662 | 0.94 | PARP1 (0.49) | PARP1CHEK2DHODHHTR1AKDM4E | |
| SCHEMBL6806267 | 0.93 | HTR1A (0.43) | PARP1HTR1AALDH1A1KDM4EPOLB | |
| SCHEMBL6799974 | 0.93 | PARP1 (0.41) | PARP1CHEK2DHODHHTR1AALDH1A1 | |
| SCHEMBL6806140 | 0.90 | DRD2 (0.44) | PARP1HTR1AALDH1A1KDM4EKMT2A | |
| SCHEMBL6810121 | 0.88 | HTR1A (0.41) | PARP1DHODHHTR1AALDH1A1KDM4E | |
| SCHEMBL6806004 | 0.88 | PARP1 (0.40) | PARP1CHEK2DHODHHTR1AALDH1A1 | |
| SCHEMBL6809929 | 0.86 | PARP1 (0.65) | PARP1CHEK2DHODHPIM1FLT3 | |
| SCHEMBL6805788 | 0.86 | PARP1 (0.67) | PARP1CHEK2DHODHPIM1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |