SCHEMBL6809935

SCHEMBL6809935

NC(O)(Cl)CCc1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.44
TAAR1 Q96RJ0 2/20 0.44
TDP1 Q9NUW8 2/20 0.44
HTR2A P28223 2/20 0.44
CYP2A6 P11509 1/20 0.44
LOXL2 Q9Y4K0 1/20 0.44
GRM2 Q14416 1/20 0.44
GRM3 Q14832 1/20 0.44
MAOA P21397 4/20 0.41
MAOB P27338 4/20 0.41
ALDH1A1 P00352 2/20 0.41
HPGD P15428 1/20 0.41
ALOX15 P16050 1/20 0.41
ALOX12 P18054 1/20 0.41
CASP1 P29466 1/20 0.41
HSD17B10 Q99714 1/20 0.41
HIF1A Q16665 1/20 0.41
SLC6A2 P23975 2/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL365214 0.98 SMN1; SMN2 (0.43) SMN1; SMN2TAAR1TDP1HTR2ACYP2A6
SCHEMBL28681602 0.82 SMN1; SMN2 (0.48) SMN1; SMN2TAAR1TDP1HTR2ACYP2A6
SCHEMBL5003745 0.82 TAAR1 (0.48) SMN1; SMN2TAAR1TDP1HTR2ACYP2A6
Hydrochloric Acid SCHEMBL8670716 0.80 MAOB (0.46) SMN1; SMN2TAAR1TDP1HTR2ACYP2A6
SCHEMBL3367528 0.78 TAAR1 (0.50) SMN1; SMN2TAAR1TDP1HTR2ACYP2A6
SCHEMBL7776472 0.78 SMN1; SMN2 (0.44) SMN1; SMN2TAAR1TDP1HTR2ACYP2A6
SCHEMBL2778837 0.77 SMN1; SMN2 (0.48) SMN1; SMN2TAAR1TDP1HTR2ACYP2A6
SCHEMBL8375787 0.77 CYP1A2 (0.47) SMN1; SMN2TAAR1TDP1HTR2ACYP2A6
SCHEMBL7196259 0.77 TDP1 (0.52) SMN1; SMN2TAAR1TDP1HTR2ACYP2A6
SCHEMBL5529047 0.77 ALDH1A1 (0.48) SMN1; SMN2TAAR1TDP1HTR2ACYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1112275-B9 NOVEL HETEROAROMATIC INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE METABASIS THERAPEUTICS INC (US) 2004-03-10 EP disclosed
EP-1112275-B1 NOVEL HETEROAROMATIC INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE METABASIS THERAPEUTICS INC (US) 2003-07-30 EP disclosed
EP-1112275-A1 NOVEL HETEROAROMATIC INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE Metabasis Therapeutics, Inc. (US) 2001-07-04 EP disclosed
WO-2000014095-A1 NOVEL HETEROAROMATIC INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE METABASIS THERAPEUTICS, INC. (US) 2000-03-16 WO disclosed
EP-0253684-B1 SUBSTAINED-RELEASE FORMULATION AND PRODUCTION THEREOF SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) 1991-04-10 EP disclosed
US-4828840-A Sustained-release formulation and production thereof SHIONOGI & CO., LTD. (JP) 1989-05-09 US disclosed
EP-0253684-A1 Substained-release formulation and production thereof SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) 1988-01-20 EP disclosed