Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL679238 | 0.90 | NPSR1 (0.46) | KMT2AGAATSHRKDM4EALDH1A1 | |
| SCHEMBL680403 | 0.85 | ALDH1A1 (0.45) | KMT2AHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL1258186 | 0.84 | KMT2A (0.46) | KMT2AGAAKDM4EALDH1A1HPGD | |
| SCHEMBL680214 | 0.82 | KMT2A (0.44) | KMT2AGAAKDM4EALDH1A1HPGD | |
| SCHEMBL680883 | 0.80 | KMT2A (0.42) | KMT2AGAATSHRKDM4EALDH1A1 | |
| SCHEMBL680328 | 0.79 | KMT2A (0.50) | KMT2AGAAKDM4EALDH1A1LMNA | |
| SCHEMBL198925 | 0.77 | IGF1R (0.50) | KMT2AGAATSHRKDM4EALDH1A1 | |
| SCHEMBL199491 | 0.73 | IGF1R (0.47) | KMT2AGAATSHRALDH1A1MEN1 | |
| SCHEMBL28344369 | 0.73 | KDM4E (0.51) | KMT2AGAATSHRHSD17B10KDM4E | |
| SCHEMBL8113306 | 0.72 | ALDH1A1 (0.42) | KMT2AGAAKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310382-B1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | LILLY CO ELI (US) | 2012-02-22 | — | — | EP | disclosed |