Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL681007 | 0.90 | KMT2A (0.45) | TSHRKMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL680891 | 0.86 | LMNA (0.42) | TSHRKMT2AALDH1A1HTTLMNA | |
| SCHEMBL1258186 | 0.82 | KMT2A (0.46) | KMT2AALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL680214 | 0.80 | KMT2A (0.44) | KMT2AALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL680883 | 0.78 | KMT2A (0.42) | NPSR1TSHRKMT2AALDH1A1KDM4E | |
| SCHEMBL680328 | 0.78 | KMT2A (0.50) | KMT2AALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL680403 | 0.75 | ALDH1A1 (0.45) | KMT2AALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL680906 | 0.73 | ALDH1A1 (0.46) | TSHRALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL8113306 | 0.70 | ALDH1A1 (0.42) | NPSR1KMT2AALDH1A1KDM4EGAA | |
| SCHEMBL16415149 | 0.69 | ALDH1A1 (0.53) | NPSR1TSHRKMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310382-B1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | LILLY CO ELI (US) | 2012-02-22 | — | — | EP | disclosed |