Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 2/20 | 0.41 |
| ▸ | MET | P08581 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | USP14 | P54578 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | USP5 | P45974 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | USP7 | Q93009 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680891 | 0.88 | LMNA (0.42) | ALDH1A1MEN1KMT2AHSD17B10SMN1; SMN2 | |
| SCHEMBL199491 | 0.88 | IGF1R (0.47) | ALDH1A1MEN1KMT2AIGF1RMET | |
| SCHEMBL681007 | 0.85 | KMT2A (0.45) | ALDH1A1MEN1KMT2AHSD17B10KDM4E | |
| SCHEMBL1259421 | 0.81 | FPR2 (0.42) | ALDH1A1MEN1KMT2AHSD17B10KDM4E | |
| SCHEMBL680508 | 0.77 | HTT (0.40) | ALDH1A1MEN1KMT2AHSD17B10KDM4E | |
| SCHEMBL198925 | 0.76 | IGF1R (0.50) | ALDH1A1MEN1KMT2AIGF1RMET | |
| SCHEMBL679238 | 0.75 | NPSR1 (0.46) | ALDH1A1MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL367875 | 0.74 | FPR2 (0.52) | ALDH1A1MEN1KMT2AHSD17B10SMN1; SMN2 | |
| SCHEMBL2676559 | 0.72 | MEN1 (0.53) | ALDH1A1MEN1KMT2AHSD17B10DRD2 | |
| SCHEMBL8260565 | 0.71 | BCHE (0.42) | ALDH1A1HSD17B10IGF1RMETKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310382-B1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | LILLY CO ELI (US) | 2012-02-22 | — | — | EP | disclosed |