Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | LTK | P29376 | 1/20 | 0.47 |
| ▸ | GRK5 | P34947 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13740452 | 0.72 | CES1 (0.43) | MAPK8MAPK9DYRK1ANOS2HTR2C | |
| SCHEMBL8429308 | 0.68 | PARP10 (0.45) | CHEK1LTKKDRHTR2AHTR2C | |
| SCHEMBL7128438 | 0.66 | PLK4 (0.45) | PLK4CHEK1AURKADAPK3PRKD3 | |
| SCHEMBL2708066 | 0.66 | DRD4 (0.51) | PLK4CHEK1AURKADAPK3PRKD3 | |
| SCHEMBL12177491 | 0.66 | DRD4 (0.47) | — | |
| SCHEMBL643615 | 0.65 | KDM4E (0.54) | LMNAKDM4EALDH1A1MAPT | |
| SCHEMBL4584548 | 0.65 | PLK4 (0.47) | PLK4CHEK1AURKADAPK3PRKD3 | |
| SCHEMBL9690326 | 0.64 | PLK4 (0.40) | PLK4CHEK1AURKADAPK3PRKD3 | |
| SCHEMBL12327868 | 0.64 | ALDH1A1 (0.49) | CHEK1LMNAPDGFRBKDM4EALDH1A1 | |
| SCHEMBL7576114 | 0.63 | NOS2 (0.39) | PLK4CHEK1AURKADAPK3PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1073435-B1 | SUBSTITUTED TRICYCLIC PYRAZOLE DERIVATIVES WITH PROTEIN KINASE ACTIVITY | ABBOTT GMBH & CO KG (DE) | 2004-07-07 | — | — | EP | disclosed |
| CN-1311678-A | substituted tricyclic pyrazole derivatives having protein kinase activity | BASF AG (DE) | 2001-09-05 | — | — | CN | disclosed |
| EP-1073435-A1 | SUBSTITUTED TRICYCLIC PYRAZOLE DERIVATIVES WITH PROTEIN KINASE ACTIVITY | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999055335-A1 | SUBSTITUTED TRICYCLIC PYRAZOLE DERIVATIVES WITH PROTEIN KINASE ACTIVITY | BASF AKTIENGESELLSCHAFT (DE) | 1999-11-04 | — | — | WO | disclosed |